27068-82-2

Basic information

• Product Name: cis-(+/-)-2,3-dihydro-3-hydroxy-2-phenyl-1,5-benzothiazepin-4(5H)-one
• CAS NO: 27068-82-2
• Molecular Weight: 271.34
• Mol File: 27068-82-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: cis-(+/-)-2,3-dihydro-3-hydroxy-2-phenyl-1,5-benzothiazepin-4(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: cis-(+/-)-2,3-dihydro-3-hydroxy-2-phenyl-1,5-benzothiazepin-4(5H)-one(27068-82-2)
• EPA Substance Registry System: cis-(+/-)-2,3-dihydro-3-hydroxy-2-phenyl-1,5-benzothiazepin-4(5H)-one(27068-82-2)

Safety Data

• Hazardous Substances Data: 27068-82-2(Hazardous Substances Data)

Upstream product

• 121-39-1 ethyl cis-3-phenylglycidate 
• 137-07-5 2-amino-benzenethiol 
• 2272-55-1 ethyl trans-3-phenyl-1-oxirane-2-carboxylate 
• 30302-04-6 3-(2-amino-phenylsulfanyl)-2-hydroxy-3-phenyl-propionic acid 
• 27068-83-3 3-(2-amino-phenylsulfanyl)-2-hydroxy-3-phenyl-propionic acid ethyl ester 
• 121-39-1 ethyl 3-phenylglycidate 
• 18509-03-0 sodium trans-cinnamate 

Downstream Products

• 5667-03-8 2-phenylbenzo[b][1,4]thiazepin-4(5H)-one 
• 47621-03-4 5-(3-dimethylamino-propyl)-2r-phenyl-3c-propionyloxy-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one 
• 47680-93-3 5-(2-dimethylamino-ethyl)-3c-hexanoyloxy-2r-phenyl-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one 
• 23515-56-2 3c-acetoxy-5-(2-dimethylamino-ethyl)-2r-phenyl-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one 
• 23515-42-6 5-(2-dimethylamino-ethyl)-3c-hydroxy-2r-phenyl-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one 
• 23515-50-6 5-(3-dimethylamino-propyl)-3c-hydroxy-2r-phenyl-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one 
• 24545-07-1 2-benzylidene-2H-1,4-benzothiazin-3(4H)-one 

Relevant articles and documents

Methods for treating leukemia and myelodysplastic syndrome, and methods for identifying agents for treating same

The present disclosure relates to methods for treating leukemia, pre-leukemic conditions, as well as myelodysplastic syndrome and acute myelogenous leukemia. The present disclosure further relates to compounds that can be used for treating leukemia, pre-leukemic conditions, as well as myelodysplastic syndrome and acute myelogenous leukemia. The present disclosure also relates to methods for identifying compounds that can be used for treating leukemia, pre-leukemic conditions, as well as myelodysplastic syndrome.

Stereoselective addition of 2-aminothiophenol to α-alkoxycinnamic acid derivatives - Alternative synthesis of (±)-diltiazem

A stereocontrolled synthesis of (±)-diltiazem by applying nucleophilic addition of 2-aminothiophenol to α-alkoxycinnamic acid derivatives is described.

Reaction of 3-Phenylglycidic Esters. Part 1. Stereoselective Opening of the Oxirane Ring of trans-3-Phenylglycidic Esters with 2-nitrothiophenols and the Effects of Various Catalysts Thereon

In the reaction of 2-nitrothiophenol (2) with trans-3-phenylglycidic esters carrying various substituents on the benzene ring, both reactivity and stereoselectivity of the oxirane ring-opening of the glycidates were markedly influenced by the electronic nature of the substituents.The presence of electron-donating groups was favourable for both reactivity and the preferential formation of cis-opening products, while the reverse was true for electron-withdrawing groups.As a result of our investigation on the catalytic effect of various Lewis acids in the reaction of the 4-methoxy derivative (1) with (2), tin compounds were found to be effective catalysts for cis-opening and readily produced the threo-nitro ester (3a), a key intermediate for the synthesis of diltiazem (5).Isolation of the crystalline complex (adduct A) from the reaction of (2) with SnCl4 and its efficient catalytic activity similar to that of SnCl4 suggest that the transition state involves co-ordination of tin derivatives both with (2) and the epoxy oxygen of (1) to cause highly specific cis-opening.