271587-47-4Relevant articles and documents
Discovery of quinolines as selective glucocorticoid receptor agonists
Jaroch, Stefan,Berger, Markus,Huwe, Christoph,Krolikiewicz, Konrad,Rehwinkel, Hartmut,Sch?cke, Heike,Schmees, Norbert,Skuballa, Werner
scheme or table, p. 5835 - 5838 (2010/11/19)
The dissociated glucocorticoid receptor (GR) agonist ZK 216348 is rendered GR-selective over other nuclear hormone receptors through replacing the methylbenzoxazine with a quinoline moiety. Compounds were shown to be efficacious in cell assays with respec
Quinol-4-ones as steroid A-ring mimetics in nonsteroidal dissociated glucocorticoid agonists
Regan, John,Lee, Thomas W.,Zindell, Renée M.,Bekkali, Younes,Bentzien, J?rg,Gilmore, Thomas,Hammach, Abdelhakim,Kirrane, Thomas M.,Kukulka, Alison J.,Kuzmich, Daniel,Nelson, Richard M.,Proudfoot, John R.,Ralph, Mark,Pelletier, Josephine,Souza, Donald,Zuvela-Jelaska, Lijiljana,Nabozny, Gerald,Thomson, David S.
, p. 7887 - 7896 (2007/10/03)
We report on the nuclear receptor binding affinities, cellular activities of transrepression and transactivation, and anti-inflammatory properties of a quinol-4-one and other A-ring mimetic containing nonsteroidal class of glucocorticoid agonists.
Nonsteroidal anti-inflammatory agents
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, (2008/06/13)
This invention describes the use of the compounds of general formula I in which A, B, A, Ar, R1, R2and R3have the meaning that is indicated in more detail in the description, for the production of pharmaceutical agents with anti-inflammatory action. The compounds of general formula I show a clear dissociation between anti-inflammatory and metabolic action.