2719-21-3

Basic information

• Product Name: 4'-ACETAMIDOACETOPHENONE
• Synonyms: 4-(Acetylamino)phenylmethylketone;4’-(Acetylamino)acetophenone;Acetamide, N-(4-acetylphenyl)-;Acetamide,N-(4-acetylphenyl)-;Acetanilide,4’-acetyl-;N-(p-acetylphenyl)acetamide;N-(4-ACETYLPHENYL)ACETAMIDE;P-ACETYLAMINOACETOPHENONE
• CAS NO: 2719-21-3
• Molecular Formula: C₁₀H₁₁NO₂
• Molecular Weight: 177.2
• EINECS: 220-320-6
• Product Categories: Aromatic Acetophenones & Derivatives (substituted);Amides;Building Blocks;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
• Mol File: 2719-21-3.mol
• Article Data: 83

Chemical Properties

• Melting Point: 166-170 °C(lit.)
• Boiling Point: 390.3 °C at 760 mmHg
• Flash Point: 177.3 °C
• Appearance: Beige/Crystalline Powder
• Density: 1.15 g/cm³
• Vapor Pressure: 2.67E-06mmHg at 25°C
• Refractive Index: 1.57
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 14.59±0.70(Predicted)
• BRN: 639749
• CAS DataBase Reference: 4'-ACETAMIDOACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-ACETAMIDOACETOPHENONE(2719-21-3)
• EPA Substance Registry System: 4'-ACETAMIDOACETOPHENONE(2719-21-3)

Safety Data

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 37/39
• WGK Germany: 2
• Hazardous Substances Data: 2719-21-3(Hazardous Substances Data)

Usage

Chemical Properties

Beige crystalline powder

InChI:InChI=1/C10H11NO2/c1-7(12)9-3-5-10(6-4-9)11-8(2)13/h3-6H,1-2H3,(H,11,13)

Upstream product

• 108-24-7 acetic anhydride 
• 62-53-3 aniline 
• 103-84-4 Acetanilid 
• 506-96-7 Acetyl bromide 
• 99-92-3 p-aminobenzophenone 
• 75-36-5 acetyl chloride 
• 52376-82-6 p-Acetamidoacetophenone semicarbazone 
• 64-19-7 acetic acid 
• 7446-70-0 aluminium trichloride 
• 60-35-5 acetamide 
• 13329-40-3 4-Iodoacetophenone 
• 350-47-0 1-(4-acetylphenyl)diazonium tetrafluoroborate 
• 75-05-8 acetonitrile 
• 127-19-5 N,N-dimethyl acetamide 

Downstream Products

• 5336-81-2 4-diethylamino-4'-acetylamino-trans-chalcone 
• 116227-91-9 N-{4-[(Z)-3-(2-Phenyl-thiazol-4-yl)-acryloyl]-phenyl}-acetamide 
• 73549-48-1 4-acetamido-α-oxophenylacetic acid 
• 68688-64-2 1-(1-acetoxy-ethyl)-4-acetylamino-benzene 
• 889469-44-7 trans-4-acetylamino-1-acetyl-cyclohexane 
• 889469-45-8 cis-4-acetylamino-1-acetyl-cyclohexane 
• 101209-08-9 4-acetamido-3-bromoacetophenone 
• 64542-29-6 1-[4-(N-acetylamino)phenyl]-1,3-butanedione 
• 130600-11-2 1-[4-(N-acetyl-N-ethylamino)phenyl]ethanone 
• 99-92-3 p-aminobenzophenone 
• 244156-32-9 2-(p-acetamidophenyl)-1,8-naphthyridine 
• 58995-76-9 2-(N-acetyl-4-aminophenyl)indole 
• 1432-42-4 1-(4-amino-3-nitrophenyl)ethanone 
• 56072-03-8 1-(4-aminophenyl)ethanone oxime 

Relevant articles and documents

Chlorination Reaction of Aromatic Compounds and Unsaturated Carbon-Carbon Bonds with Chlorine on Demand

Chlorination with chlorine is straightforward, highly reactive, and versatile, but it has significant limitations. In this Letter, we introduce a protocol that could combine the efficiency of electrochemical transformation and the high reactivity of chlorine. By utilizing Cl3CCN as the chloride source, donating up to all three chloride atom, the reaction could generate and consume the chlorine in situ on demand to achieve the chlorination of aromatic compounds and electrodeficient alkenes.

Z-Selective Fluoroalkenylation of (Hetero)Aromatic Systems by Iodonium Reagents in Palladium-Catalyzed Directed C?H Activation

The direct and catalytic incorporation of fluorine containing molecular motifs into organic compounds resulting high-value added chemicals represents a rapidly evolving part of synthetic methodologies, thus this area is in the focus of pharmaceutical and agrochemical research. Herein we report a stereoselective procedure for direct fluorovinylation of aromatic and heteroaromatic scaffolds. This methodology development has been realized by palladium-catalyzed ortho C?H activation reaction of aniline derivatives featuring the regioselectivity via directing groups such as secondary of tertiary amides, ureas or ketones. The application of non-symmetrical aryl(fluoroalkenyl)-iodonium salts as fluoroalkenylating agents allowed mild reaction conditions in general for this transformation. The scope and limitations have been thoroughly investigated and the feasibility has been demonstrated by more than 50 examples.

Catalyst-free generation of acyl radicals induced by visible light in water to construct C-N bonds

We describe herein a catalyst-free and redox-neutral photochemical strategy for the direct generation of acyl radicals from α-diketones, and its selective conversion of nitrosoarenes to hydroxyamides or amides with AcOH or NaCl as an additive. The reaction was carried out under mild conditions in water with purple LEDs as the light source. A broad scope of substrates was demonstrated. Mechanistic experiments indicate that α-diketones cleave to give acyl radicals, with hydroxyamides being further reduced to amides.