272769-49-0 Usage
General Description
2-(1-propyl-4-piperidinyl)-1H-benzimidazole-7-carboxamide, also known as P7C3-A20, is a chemical compound with potential neuroprotective properties. It belongs to the class of benzimidazole carboxamides and has been studied for its potential in treating neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. P7C3-A20 has been found to promote the survival of newborn neurons in the brain, which could have significant implications for the treatment of various neurological disorders. Its mechanism of action involves increasing the levels of nicotinamide adenine dinucleotide (NAD) and reducing DNA damage, ultimately leading to enhanced neuronal survival. Further research is ongoing to explore the therapeutic potential of this compound in various neurodegenerative conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 272769-49-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,7,2,7,6 and 9 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 272769-49:
(8*2)+(7*7)+(6*2)+(5*7)+(4*6)+(3*9)+(2*4)+(1*9)=180
180 % 10 = 0
So 272769-49-0 is a valid CAS Registry Number.
InChI:InChI=1/C16H22N4O/c1-2-8-20-9-6-11(7-10-20)16-18-13-5-3-4-12(15(17)21)14(13)19-16/h3-5,11H,2,6-10H2,1H3,(H2,17,21)(H,18,19)
272769-49-0Relevant articles and documents
Process development for ABT-472, a benzimidazole PARP inhibitor
Barkalow, Jufang H.,Breting, Jeffrey,Gaede, Bruce J.,Haight, Anthony R.,Henry, Rodger,Kotecki, Brian,Mei, Jianzhang,Pearl, Kurt B.,Tedrow, Jason S.,Viswanath, Shekhar K.
, p. 693 - 698 (2012/12/29)
A nine-step convergent process was developed for the synthesis of ABT-472, a benzimidazole PARP inhibitor. The identity and origin of several impurities were determined, and the process was modified to reduce or eliminate these impurities. A number of safety and control issues were investigated. The original synthesis was shortened to 9 steps and streamlined while maintaining a convergent strategy. A stable salt was selected, and control of the API solid form was established. The process was successfully scaled up to provide 8.5 kg of final product of >99% purity in 33% yield over 9 steps.
