27314-97-2Relevant articles and documents
A redox-activatable biopolymer-based micelle for sequentially enhanced mitochondria-targeted photodynamic therapy and hypoxia-dependent chemotherapy
Fei, Yang,Hou, Yanhua,Hu, Yan,Li, Menghuan,Li, Yanan,Luo, Zhong,Sutrisno, Linawati,Xue, Chengcheng
, p. 9978 - 9981 (2020)
A tumor redox-activatable micellar nanoplatform based on the naturally occurring biomacromolecule hyaluronic acid (HA) was developed for complementary photodynamic/chemotherapy against CD44-positive tumors. Here HA was first conjugated with l-carnitine (Lc)-modified zinc phthalocyanine (ZnPc) via disulfide linkage and then co-assembled with tirapazamine (TPZ) to afford the physiologically stable micellar nanostructure. The mitochondria-targeted photodynamic activity of ZnPc-Lc could efficiently activate the mitochondrial apoptosis cascade and deplete the oxygen in the tumor intracellular environment to amplify the hypoxia-dependent cytotoxic effect of TPZ.
Synthesis, crystal structure and calculation of oxides of 2-methylamino-3-methyl quinoxaline
Li, Junjian,Wang, Rui,Wang, Wenfeng,Wang, Xucheng,Yuan, Yaofeng,Zhang, Min
, (2020/07/27)
Monoxide and dioxide of animo quinoxaline were synthesized and characterized by 1H NMR, 13C NMR and HRMS. The result shows that monoxide is main product. 1H NMR analysis, quantum calculation and crystal structure all indicate that the monoxide is 4-oxide structure but not 1-oxide structure. The subsequent discussions of electronic effect and steric effect of 1-oxide and 4-oxide support the conclusion that 4-oxide is dominant product, which is consistent with 1H NMR analysis and crystal structure. At last, the calculated structure is in good agreement with the crystal structure in this paper, which indicates that the calculation result in this paper is credible.
3 - Amido - 1, 2, 4 - benzene and three qinqin kinds in use in the preparation of a tumor sensitizer
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Paragraph 0041-0043, (2018/04/20)
The invention relates to compounds which have a general formula (I), and pharmaceutically acceptable medicinal salt of the compounds which have the general formula (I), wherein R is defined in the specifications. The invention also discloses a preparation method for 3-acylamino-1,2,4-phentriazine derivatives, and a sensibilization effect of the 3-acylamino-1,2,4-phentriazine derivatives in the radiotherapy and chemotherapy of tumor.