27393-85-7

Basic information

• Product Name: 2-(1H-indol-3-yl)-1H-indole
• CAS NO: 27393-85-7
• Molecular Formula: C₁₆H₁₂N₂
• Molecular Weight: 232.285
• Mol File: 27393-85-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 525°Cat760mmHg
• Flash Point: 246.9°C
• Density: 1.293g/cm³
• CAS DataBase Reference: 2-(1H-indol-3-yl)-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1H-indol-3-yl)-1H-indole(27393-85-7)
• EPA Substance Registry System: 2-(1H-indol-3-yl)-1H-indole(27393-85-7)

Safety Data

• Hazardous Substances Data: 27393-85-7(Hazardous Substances Data)

Usage

General Description

2-(1H-indol-3-yl)-1H-indole, also known as 3-(2-indolyl) indole, is a chemical compound consisting of two fused indole rings. It is a heterocyclic aromatic compound with potential applications in pharmaceutical and organic synthesis. Its molecular structure and properties make it suitable for use as a building block in the synthesis of complex organic molecules, and it has been the subject of research for its potential pharmacological activities. The compound is also known for its fluorescence properties, making it useful in fluorescence-based analytical techniques and assays. Overall, 2-(1H-indol-3-yl)-1H-indole is a versatile compound with potential applications in various fields of chemistry and biology.

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Relevant articles and documents

Convenient and scalable process for the preparation of indole via raney nickel-catalyzed hydrogenation and ring closure

An efficient and practical method for the synthesis of indole as a key starting material for many useful chemicals is described. Using 2-nitrotoluene as starting material, hydroxymethylation with formaldehyde under alkaline conditions gave 2-(2-nitrophenyl) ethanol on a large scale. Raney Ni catalyst was used for both reduction of the nitro group as well as for the indole formation. The overall yield was 78% from 2-nitrotoluene. Copyright

Nucleophilic substitution reaction at the 1-position of 1-hydroxytryptamine and -tryptophan derivatives

A novel nucleophilic substitution reaction at the 1-position of indole nucleus was discovered by reacting 1-hydroxytryptamine and -tryptophan derivatives with indoles in 85% formic acid yielding 1-(indol-3-yl)indoles. Their structures were determined by X-Ray crystallographic analysis and chemical correlations. An SN2 mechanism on the indole nitrogen (1-position) is proposed.

SYNTHESIS AND CHARACTERIZATION OF NEW INDOLE TRIMERS AND TETRAMERS

A new method has been achieved to synthesize indole trimers and tetramers starting from indoles and 3-bromoindoles.Unusual open and cyclic trimers have been isolated and characterized, and the mechanism of formation is proposed.