274-95-3

Basic information

• Product Name: Imidazo[1,2-a]pyrimidine
• Synonyms: 1,8-Diazaindolizine;1,3a,7-Triazaindene;IMIDAZO[1,2-A]PYRIMIDINE
• CAS NO: 274-95-3
• Molecular Formula: C₆H₅N₃
• Molecular Weight: 119.12
• Product Categories: Pyrimidines;Fused Ring Systems;Heterocycle-Pyrimidine series;Fluorobenzene
• Mol File: 274-95-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: 127-129°
• Appearance: /
• Density: 1.294 g/cm³
• Refractive Index: 1.689
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 5.50±0.30(Predicted)
• CAS DataBase Reference: Imidazo[1,2-a]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: Imidazo[1,2-a]pyrimidine(274-95-3)
• EPA Substance Registry System: Imidazo[1,2-a]pyrimidine(274-95-3)

Safety Data

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37
• HazardClass: IRRITANT
• Hazardous Substances Data: 274-95-3(Hazardous Substances Data)

Usage

General Description

Imidazo[1,2-a]pyrimidine is a heterocyclic compound with a fused imidazole and pyrimidine ring system. It is a versatile building block in organic synthesis and is used as a core structure in a variety of biologically active compounds, including pharmaceuticals and agrochemicals. Imidazo[1,2-a]pyrimidine derivatives exhibit a wide range of biological activities, such as antiviral, anticancer, antifungal, and antibacterial properties. Due to its pharmacological potential, imidazo[1,2-a]pyrimidine derivatives have attracted significant attention from researchers and are the subject of ongoing drug discovery efforts. Additionally, they also have potential applications in materials science and as ligands in coordination chemistry.

InChI:InChI=1/C6H5N3/c1-2-7-6-8-3-5-9(6)4-1/h1-5H

Upstream product

• 109-12-6 2-aminopyrimidine 
• 2032-35-1 Bromoacetaldehyde diethyl acetal 
• 764-63-6 (E)-3-ethoxyacrylaldehyde 
• 1450-93-7 2-aminoimidazole hemisulfate 
• 122-31-6 malondialdehyde bis(diethyl acetal) 
• 107-20-0 2-chloroethanal 

Downstream Products

• 6840-45-5 3-bromoimidazo[1,2-a]pyrimidine 
• 798568-24-8 3-nitroimidazo<1,2-a>pyridimine 
• 67139-22-4 5,6,7,8-tetrahydroimidazo[1,2-a]pyrimidine 
• 143696-95-1 3-chloroimidazolo[1,2-a]pyrimidine 
• 106012-56-0 3-formylimidazo<1,2-a>pyrimidine 
• 39573-70-1 7-phenylimidazo<1,2-a>pyridine 

Relevant articles and documents

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Organic compound comprising pyrimidine and organic electroluminescent device comprising the same

The present invention relates to an organic aromatic organic compound containing pyridine, and an organic electroluminescent device using the same, wherein the compound may be used as thermally activated delayed fluorescent (TADF) material due to having little energy difference between an excited singlet state and an excited triplet state. Further, the compound of the present invention may be used in an organic light-emitting diode to improve efficiency of the organic light-emitting diode and lower driving voltage thereof.COPYRIGHT KIPO 2017

Synthesis and antibacterial activity of some imidazo[1,2-a[pyrimidine derivatives

A series of 75 imidazo[1,2-a]pyrimidine derivatives were synthesized. The 'in vitro' antibacterial activity of these compounds and their corresponding α-bromoketones against a variety of gram (+), gram (-) bacteria and Mycobacterium species is reported. Some of the prepared derivatives exhibited potent antimicrobial activity.