27465-51-6Relevant articles and documents
Selective electrochemical oxidation of aromatic hydrocarbons and preparation of mono/multi-carbonyl compounds
Li, Zhibin,Zhang, Yan,Li, Kuiliang,Zhou, Zhenghong,Zha, Zhenggen,Wang, Zhiyong
, p. 2134 - 2141 (2021/09/29)
A selective electrochemical oxidation was developed under mild condition. Various mono-carbonyl and multi-carbonyl compounds can be prepared from different aromatic hydrocarbons with moderate to excellent yield and selectivity by virtue of this electrochemical oxidation. The produced carbonyl compounds can be further transformed into α-ketoamides, homoallylic alcohols and oximes in a one-pot reaction. In particular, a series of α-ketoamides were prepared in a one-pot continuous electrolysis. Mechanistic studies showed that 2,2,2-trifluoroethan-1-ol (TFE) can interact with catalyst species and generate the corresponding hydrogen-bonding complex to enhance the electrochemical oxidation performance. [Figure not available: see fulltext.]
Method for preparing alpha-alkyl substituted ketone compound
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Paragraph 0165-0172, (2020/12/29)
The invention relates to a method for preparing an alpha-alkyl substituted ketone compound, which comprises the following steps: preparing a primary alcohol compound and a secondary alcohol compound as raw materials, adding alkali; with a cyclic iridium complex as a catalyst and water as a reaction medium, heating and stirring the mixture and reacting for 10 to 24 hours under the protection of inert gas, and cooling a reaction product to room temperature after the reaction is finished; carrying out reduced pressure distillation and concentration to obtain a crude product, and carrying out column chromatography purification to obtain a series of alpha alkyl substituted ketone compounds. The method is simple to operate, available in raw materials, low in price, high in reaction efficiency and selectivity, good in adaptability to various functional groups and wide in substrate universality; since water is used as a reaction medium to meet the green and environment-friendly requirements, the method is environmentally friendly and is carried out at gram level, so that the potential of industrially synthesizing the alpha alkyl substituted ketone compound is achieved; therefore, The method has expanded application in the fields of medicines, organic synthesis and the like.
Method for generating ketone through rearranging diazo compounds under catalysis condition of ferrous sulfate heptahydrate
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Paragraph 0018; 0019; 0020; 0021; 0023; 0030; 0031; 0032, (2018/09/08)
The invention provides a method for generating ketone through rearranging diazo compounds to remove one molecule of nitrogen gas and one molecule of carbon dioxide under a certain condition. The method comprises the following steps of adding diazo compound 2-diazo-1-phenylbutane-1,3-diketone and iron sulfate heptahydrate into a reaction container; then adding methylbenzene; performing stirring reaction for 12 hours at 100 DEG C; after the reaction is completed, performing filtering by a kieselguhr sand core funnel; after rotary drying, performing column separation to obtain pure products. Thepreparation method is simple and convenient; the cost is low; the conditions are mild; the yield can reach 80 percent or higher. The method belongs to a novel method for generating ketone. A positiveresearch is provided for the application of the compound.
