27473-61-6

Basic information

• Product Name: 1',3'-DIHYDRO-SPIRO(IMIDAZOLIDINE-4,2'-(2H)INDENE)-2,5-DIONE
• Synonyms: 1',3'-DIHYDRO-SPIRO(IMIDAZOLIDINE-4,2'-(2H)INDENE)-2,5-DIONE;AKOS 146;S.2-712;Spiro[indane-2,4'-imidazolidine]-2',5'-dione;1',3'-Dihydrospiro[iMidazolidine-4,2'-indene]-2,5-dione
• CAS NO: 27473-61-6
• Molecular Formula: C₁₁H₁₀N₂O₂
• Molecular Weight: 202.21
• Mol File: 27473-61-6.mol
• Article Data: 19

Chemical Properties

• Melting Point: 260-267 °C(Solv: ethanol (64-17-5))
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.4g/cm³
• PKA: 10.29±0.20(Predicted)
• CAS DataBase Reference: 1',3'-DIHYDRO-SPIRO(IMIDAZOLIDINE-4,2'-(2H)INDENE)-2,5-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1',3'-DIHYDRO-SPIRO(IMIDAZOLIDINE-4,2'-(2H)INDENE)-2,5-DIONE(27473-61-6)
• EPA Substance Registry System: 1',3'-DIHYDRO-SPIRO(IMIDAZOLIDINE-4,2'-(2H)INDENE)-2,5-DIONE(27473-61-6)

Safety Data

• Hazardous Substances Data: 27473-61-6(Hazardous Substances Data)

Usage

Description

1',3'-DIHYDRO-SPIRO(IMIDAZOLIDINE-4,2'-(2H)INDENE)-2,5-DIONE is a heterocyclic chemical compound characterized by a unique spiro-indene structure. It features an imidazolidine ring and a diketone functionality, which may contribute to its potential pharmacological properties. 1',3'-DIHYDRO-SPIRO(IMIDAZOLIDINE-4,2'-(2H)INDENE)-2,5-DIONE could be valuable in the development of new drugs or as a building block for organic synthesis, although further research is required to explore its full potential.

Uses

Used in Pharmaceutical Development:
1',3'-DIHYDRO-SPIRO(IMIDAZOLIDINE-4,2'-(2H)INDENE)-2,5-DIONE is used as a potential candidate in pharmaceutical development due to its distinctive structure and possible pharmacological properties. Its imidazolidine ring and diketone functionality may offer unique interactions with biological targets, making it a promising compound for the creation of new drugs.
Used in Organic Synthesis:
In the field of organic synthesis, 1',3'-DIHYDRO-SPIRO(IMIDAZOLIDINE-4,2'-(2H)INDENE)-2,5-DIONE serves as a building block for the creation of more complex molecules. Its spiro-indene structure and heterocyclic nature provide a foundation for the development of novel chemical entities with diverse applications in various industries.
Further research is necessary to fully understand the potential uses and properties of 1',3'-DIHYDRO-SPIRO(IMIDAZOLIDINE-4,2'-(2H)INDENE)-2,5-DIONE, as its current applications are based on its structural features and the possibilities they present.

Upstream product

• 773837-37-9 sodium cyanide 
• 615-13-4 2-indanone 
• 143-33-9 sodium cyanide 
• 506-87-6 ammonium carbonate 
• 151-50-8 potassium cyanide 

Downstream Products

• 1401008-12-5 C₂₇H₂₄F₆N₄O₄ 
• 1210815-86-3 5'-bromo-1-(4-methoxybenzyl)-3-methyl-1',3'-dihydro-2H,5H-spiro[imidazolidine-4,2'-indene]-2,5-dione 
• 1210815-85-2 5'-bromo-1-(4-methoxybenzyl)-1',3'-dihydro-2H,5H-spiro[imidazolidine-4,2'-indene]-2,5-dione 
• 1398717-91-3 (S)-2-amino-N-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethyl)-2,3-dihydro-1H-indene-2-carboxamide 
• 1398718-54-1 (S)-tert-butyl 2-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethylcarbamoyl)-2,3-dihydro-1H-inden-2-ylcarbamate 
• 33584-66-6 (+/-)-5'-nitro-1',3'-dihydro-2H,5H-spiro[imidazolidine-4,2'-indene]-2,5-dione 
• 1240303-22-3 C₁₁H₉N₃O₄ 
• 199330-64-8 2-amino-indane-2-carboxylic acid methyl ester hydrochloride 
• 71066-00-7 2-((tert-butoxycarbonyl)amino)-2,3-dihydro-1H-indene-2-carboxylic acid 
• 905278-33-3 1,3-dibenzyl-4-hydroxyspiro(imidazolidin-5,2'-indane)-2-one 
• 905278-48-0 1,3-dibenzyl-4,9-dihydrobenzo[f]benzimidazol-2-one 
• 905278-41-3 3-benzyl-4-hydroxyspiro(imidazolidin-5,2'-indane)-2-one 
• 905278-23-1 3-benzylspiro(imidazolidin-5,2'-indane)-2,4-dione 
• 905278-22-0 1,3-dibenzylspiro(imidazolidin-5,2'-indane)-2,4-dione 

Relevant articles and documents

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ALIPHATIC SPIROLACTAM CGRP RECEPTOR ANTAGONISTS

The present invention is directed to aliphatic spirolactam derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmaceutical\compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

PIPERIDINE CARBOXAMIDE SPIROHYDANTOIN CGRP RECEPTOR ANTAGONISTS

The present invention is directed to piperidinone carboxamide spirohydantoin derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also d