27613-36-1

Basic information

• Product Name: Benzonitrile, 5-formyl-2-methyl- (9CI)
• Synonyms: Benzonitrile, 5-formyl-2-methyl- (9CI);3-Cyano-4-Methylbenzaldehyde;5-methanoyl-2-methyl-benzonitrile
• CAS NO: 27613-36-1
• Molecular Formula: C₉H₇NO
• Molecular Weight: 145.15798
• Product Categories: ALDEHYDE
• Mol File: 27613-36-1.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: Benzonitrile, 5-formyl-2-methyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 5-formyl-2-methyl- (9CI)(27613-36-1)
• EPA Substance Registry System: Benzonitrile, 5-formyl-2-methyl- (9CI)(27613-36-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 27613-36-1(Hazardous Substances Data)

Usage

Uses

5-Formyl-2-methylbenzonitrile can be used as antitumor agents.

Upstream product

• 156001-51-3 3-Bromo-6-methyl-benzonitrile 
• 68-12-2 N,N-dimethyl-formamide 
• 80466-34-8 2,4-hexadienal 
• 2407-68-3 3-dimethylaminoacrylonitrile 
• 315188-34-2 5-(hydroxymethyl)-2-methylbenzonitrile 

Downstream Products

• 1598417-32-3 4-(2-(4-(3-cyano-4-methylbenzylamino)piperidin-1-yl)ethyl)-6-methoxyquinoline-3-carbonitrile 
• 1598418-21-3 4-(3-cyano-4-methyl-benzylamino)-piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Redox neutral [4+2] benzannulation of dienals and tertiary enaminones for benzaldehyde synthesis

By employing the featured amine elimination of tertiary enaminones as a key transformation, cascade reactions of dienals and tertiary enaminones involving [4+2] annulation, Hofmann-like amine elimination and aromatization are devised for benzaldehyde synthesis. This method is of particular interest in providing benzaldehydes containing an electron withdrawing group at the C3 position which are hard to access by previous methods for benzaldehyde synthesis.

PYRIDINONE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS AGAINST HIV INFECTED CELLS

The present disclosure is directed to pyridinone derivatives of Formula I and their use for selectively killing HIV infected GAG-POL expressing cells without concomitant cytotoxicity to HIV nave cells, and for the treatment of infection by HIV, or for the treatment, prophylaxis or delay in the onset or progression of AIDS or AIDS Related Complex (ARC).