27648-87-9

Basic information

• Product Name: Acetic acid,2,2'-[1,2-phenylenebis(oxy)]bis-, 1,1'-dimethyl ester
• Synonyms: Aceticacid, (o-phenylenedioxy)di-, dimethyl ester (8CI); Acetic acid,2,2'-[1,2-phenylenebis(oxy)]bis-, dimethyl ester (9CI);1,2-Bis(methoxycarbonylmethoxy)benzene; Benzene-1,2-dioxyacetic acid dimethylester; NSC 406759
• CAS NO: 27648-87-9
• Molecular Formula: C12H14 O6
• Molecular Weight: 254.24
• Mol File: 27648-87-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Acetic acid,2,2'-[1,2-phenylenebis(oxy)]bis-, 1,1'-dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid,2,2'-[1,2-phenylenebis(oxy)]bis-, 1,1'-dimethyl ester(27648-87-9)
• EPA Substance Registry System: Acetic acid,2,2'-[1,2-phenylenebis(oxy)]bis-, 1,1'-dimethyl ester(27648-87-9)

Safety Data

• Hazardous Substances Data: 27648-87-9(Hazardous Substances Data)

Upstream product

• 120-80-9 benzene-1,2-diol 
• 96-34-4 methyl chloroacetate 
• 96-32-2 bromoacetic acid methyl ester 

Downstream Products

• 5411-14-3 2-[2-(2-hydroxy-2-oxoethoxy)phenoxy]acetic acid 
• 931424-53-2 N-(3-dimethylamino-3,4-dihydro-2H-benzo[b][1,4]dioxepin-3-ylmethyl)-2-(4-methoxymethylene-cyclohexyl)-acetamide 
• 931424-52-1 N-(3-dimethylamino-3,4-dihydro-2H-benzo[b][1,4]dioxepin-3-ylmethyl)-2-(4-oxo-cyclohexyl)-acetamide 
• 779340-90-8 methyl (4-iodo-2-methoxycarbonylmethoxy-phenoxy)acetate 

Relevant articles and documents

The synthesis of macrocyclic diamides and tetramides containing phenol units

Thirteen new macrocyclic diamides and tetramides have been synthesized by reaction of methyl phenoxyacetates (readily obtained from various phenols) with α,ω-diamines in methanol as a solvent. Relationship between structure of esters and ratio of diamides to tetraamides has been investigated.

Synthesis of benzodioxepinone analogues via a novel synthetic route with qualitative olfactory evaluation

Marine odorants represent a minor yet diverse class of substances within the fragrance industry, of which 7-methyl-2H-1,5-benzodioxepin-3(4H)-one (1) is commercially known as Calone 1951, a synthetic first in the area of marine-fragrance chemistry. To determine the extent to which the characteristic marine odor of Calone 1951 corresponds to the substitution at the benzo portion of the molecule, a variety of aromatic substituents were incorporated into the benzodioxepinone structure (Scheme 1, Table 3). In light of the difficulty experienced in applying patented literature to deriving the analogues 12-18, particularly those with electron-withdrawing substituents, an alternative synthetic scheme was implemented for the construction of all analogues in favorable yields (Scheme 4, Table 3). Formation of the hydroxy-protected dihalo alkylating agent 24 via epoxide cleavage of epichlorohydrin (Scheme 3) allowed etherification favoring dihalo displacement and subsequent intramolecular ring closure (-→26a-g). THP Deprotection followed by oxidation of the alcohols 27a-g to the ketones 12-18 provided a general pathway to the benzodioxepinone products. The influence of the substituent nature on odor activity revealed a diverse scope of olfactory character (Table 4).

Iodinated biaryls synthesized by the direct dehydrodimerization of iodoarenes using phenyliodine(III) bis(trifluoroacetate) (PIFA)

Multiply iodinated biaryls can be prepared in yields up to 75% by direct oxidative coupling reaction of the iodinated arenes. The PIFA-mediated dehydrodimerization is superior to all other known methods. The developed protocol is reliable and easy to perform.