2765-16-4

Basic information

• Product Name: Benzene, 1,1'-(1,2-ethynediyl)bis[3-methyl-
• CAS NO: 2765-16-4
• Molecular Formula: C16H14
• Molecular Weight: 206.287
• Mol File: 2765-16-4.mol
• Article Data: 51

Chemical Properties

• CAS DataBase Reference: Benzene, 1,1'-(1,2-ethynediyl)bis[3-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1,1'-(1,2-ethynediyl)bis[3-methyl-(2765-16-4)
• EPA Substance Registry System: Benzene, 1,1'-(1,2-ethynediyl)bis[3-methyl-(2765-16-4)

Safety Data

• Hazardous Substances Data: 2765-16-4(Hazardous Substances Data)

Usage

General Description

"Benzene, 1,1'-(1,2-ethynediyl)bis[3-methyl-" is a complex organic chemical compound that belongs to the family of aromatic hydrocarbons. It is commonly used in the manufacturing of a variety of chemical products. The compound contains two benzene rings, each substituted with a methyl group, and is linked together by an ethynediyl bridge. Like other benzene derivatives, it should be handled with caution as prolonged exposure can potentially lead to health issues. While it plays a significant role in various chemical reactions and industrial applications, its production and use should be managed carefully due to its potential environmental impact.

Upstream product

• 1711-06-4 3-Methylbenzoyl chloride 
• 625-95-6 3-Iodotoluene 
• 74-86-2 acetylene 
• 18826-62-5 1-methyl-3-(prop-1-yn-1-yl)benzene 
• 35286-92-1 (E)-3,3'-dimethylstilbene 
• 766-82-5 1-ethynyl-3-methyl-benzene 
• 1066-54-2 trimethylsilylacetylene 
• 624-31-7 4-tolyl iodide 
• 591-17-3 meta-bromotoluene 
• 471-25-0 Propiolic acid 
• 5963-39-3 hex-3-yne-1,6-dioic acid 
• 63024-77-1 3-(Chloromethyl)benzoyl chloride 
• 75-20-7 calcium carbide 
• 115-19-5 2-methyl-but-3-yn-2-ol 

Downstream Products

• 4463-26-7 3,3'-dimethylbenzil 
• 132733-33-6 3,4-Di(m-tolyl)-1,2,5-thiadiazole 
• 32383-70-3 (E)-2,3-bis(m-tolyl)acrylic acid 
• 1383663-47-5 (Z)-1-(1,2-di-m-tolylvinyl)-5-methoxy-1H-indole 
• 1427041-77-7 3-(4-chlorophenyl)-Z-4-ethylidene-2-methyl-3,4-dihydroisoquinolinone 
• 1427041-78-8 C₁₈H₁₆ClNO 
• 1449795-60-1 C₂₅H₁₉NO₂ 
• 3262-39-3 1,2-bis(3-methylphenyl)ethylene 

Relevant articles and documents

Selective Synthesis of Non-Aromatic Five-Membered Sulfur Heterocycles from Alkynes by using a Proton Acid/N-Chlorophthalimide System

A multicomponent strategy to achieve two different regioselectivities from alkynes, isothiocyanates and H2O with a proton acid/N-chlorophthalimide (NCPI) system is described to selectively obtain non-aromatic five-membered sulfur heterocycles (1,3-oxathiol-2-imines/thiazol-2(3H)-one derivatives) through multiple bond formations. The process features readily available starting materials, mild reaction conditions, broad substrate scope, good functional-group tolerance, high regio- and chemo- selectivities, gram-scale synthesis and late-stage modifications. Mechanistic studies support the proposal that the transformation process includes a combination of H2O and isothiocyanate, free-radical formation, carbonation and intramolecular cyclization to give the products. Furthermore, the 1,3-oxathiol-2-imine derivatives possess unique fluorescence characteristics and can be used as Pd2+ sensors with a “turn-off” response, demonstrating potential applications in environmental and biological fields.

Iodonium Cation-Pool Electrolysis for the Three-Component Synthesis of 1,3-Oxazoles

The synthesis of 1,3-oxazoles from symmetrical and unsymmetrical alkynes was realized by an iodonium cation-pool electrolysis of I2 in acetonitrile with a well-defined water content. Mechanistic investigations suggest that the alkyne reacts with the acetonitrile-stabilized I+ ions, followed by a Ritter-type reaction of the solvent to a nitrilium ion, which is then attacked by water. The ring closure to the 1,3-oxazoles released molecular iodine, which was visible by the naked eye. Also, some unsymmetrical internal alkynes were tested and a regioselective formation of a single isomer was determined by two-dimensional NMR experiments.

Nickel-Catalyzed One-Pot Carbonylative Synthesis of 2-Mono- And 2,3-Disubstituted Thiochromenones from 2-Bromobenzenesulfonyl Chlorides and Alkynes

A nickel-catalyzed one-pot carbonylation reaction of 2-bromobenzenesulfonyl chlorides with alkynes for the synthesis of thiochromenones has been established. Both terminal and internal alkynes were suitable substrates in this carbonylative transformation, and a broad range of 2-mono- and 2,3-disubstituted thiochromenone products were obtained in moderate to good yields with quite high functional group compatibility. Notably, this procedure presents the first example of nickel-catalyzed carbonylative synthesis of thiochromenones with 2-bromobenzenesulfonyl chlorides as a promising sulfur precursor.