27687-36-1

Basic information

• Product Name: 3-hydroxy-2-isopropyl-3-phenyl-2,3-dihydroisoindol-1-one
• Synonyms: 3-hydroxy-2-isopropyl-3-phenyl-2,3-dihydroisoindol-1-one
• CAS NO: 27687-36-1
• Molecular Weight: 267.327
• Mol File: 27687-36-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 3-hydroxy-2-isopropyl-3-phenyl-2,3-dihydroisoindol-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-2-isopropyl-3-phenyl-2,3-dihydroisoindol-1-one(27687-36-1)
• EPA Substance Registry System: 3-hydroxy-2-isopropyl-3-phenyl-2,3-dihydroisoindol-1-one(27687-36-1)

Safety Data

• Hazardous Substances Data: 27687-36-1(Hazardous Substances Data)

Upstream product

• 18852-53-4 3-chloro-3-phenylphthalide 
• 75-31-0 isopropylamine 
• 5440-69-7 N-isopropylbenzamide 
• 100-52-7 benzaldehyde 
• 98-88-4 benzoyl chloride 
• 22103-85-1 2-benzoylbenzoyl chloride 
• 85-52-9 2-Benzoylbenzoic acid 
• 312924-64-4 C₁₇H₁₈FNO 
• 393-52-2 2-Fluorobenzoyl chloride 
• 64141-92-0 N-isopropyl-2-iodobenzamide 
• 140-29-4 phenylacetonitrile 

Relevant articles and documents

On the Effect of Secondary Nucleation on Deracemization through Temperature Cycles

Herein, the pivotal role of secondary nucleation in a crystallization-enhanced deracemization process is reported. During this process, complete and rapid deracemization of chiral conglomerate crystals of an isoindolinone is attained through fast microwave-assisted temperature cycling. A parametric study of the main factors that affect the occurrence of secondary nucleation in this process, namely agitation rate, suspension density, and solute supersaturation, confirms that an enhanced stereoselective secondary nucleation rate maximizes the deracemization rate. Analysis of the system during a single temperature cycle showed that, although stereoselective particle production during the crystallization stage leads to enantiomeric enrichment, undesired kinetic dissolution of smaller particles of the preferred enantiomer occurs during the dissolution step. Therefore, secondary nucleation is crucial for the enhancement of deracemization through temperature cycles and as such should be considered in further design and optimization of this process, as well as in other temperature cycling processes commonly applied in particle engineering.

Base-promoted cascade C-C coupling/N-α-sp3C-H hydroxylation for the regiospecific synthesis of 3-hydroxyisoindolinones

A base-promoted cascade reaction for the regiospecific synthesis of substituted 3-hydroxyisoindolinones under transition-metal-free conditions is developed. The base-mediated C-C bond coupling and N-α-sp3C-H bond hydroxylation are involved in t

Tandem Rh(III)-catalyzed oxidative acylation of secondary benzamides with aldehydes and intramolecular cyclization: The direct synthesis of 3-hydroxyisoindolin-1-ones

The rhodium-catalyzed oxidative acylation between secondary benzamides and aryl aldehydes via sp2 C - H bond activation followed by an intramolecular cyclization is described. This method results in the direct and efficient synthesis of 3-hydro