278605-36-0Relevant articles and documents
Preparation of chiral α-monofluoroalkylphosphonic acids and their evaluation as inhibitors of protein tyrosine phosphatase 1B
Kotoris, Christopher C.,Wen, Wcndy,Lough, Alan,Taylor, Scott D.
, p. 1271 - 1281 (2000)
Enantiomerically pure α-monofluoroalkylphosphonic acids 4-9 were synthesized by diastereoselective electrophilic fluorination of α-carbanions of asymmetric phosphonamidates bearing (-)-ephedrine as a chiral auxiliary. The diastereomeric excess of the fluo