278788-66-2

Basic information

• Product Name: (R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• Synonyms: (R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;(R)-4-N-BOC-2-HYDROXYMETHYL-PIPERAZINE;(R)-1-Boc-3-hydroxymethyl-piperazine;(R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate;H57159;(R)-4-Boc-2-hydroxymethyl-piperazine;1-Piperazinecarboxylic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester, (3R)-;(R)-1-Boc-3-(Hydroxymethyl)piperazine ,98%
• CAS NO: 278788-66-2
• Molecular Formula: C₁₀H₂₀N₂O₃
• Molecular Weight: 216.28
• Product Categories: pharmacetical;Piperaizine
• Mol File: 278788-66-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 322.9 °C at 760 mmHg
• Flash Point: 149.1 °C
• Appearance: /
• Density: 1.085 g/cm³
• Vapor Pressure: 2.15E-05mmHg at 25°C
• Refractive Index: 1.477
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 14.97±0.10(Predicted)
• CAS DataBase Reference: (R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(278788-66-2)
• EPA Substance Registry System: (R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(278788-66-2)

Safety Data

• Hazard Codes: Xi
• Statements: 41-52
• Safety Statements: 26-39
• Hazardous Substances Data: 278788-66-2(Hazardous Substances Data)

Usage

Uses

(R)-1-Boc-3-hydroxymethylpiperazine is a used as a building block for the preparation of PI3K inhibitors for rheumatoid arthritis treatment,benzoxaborole derivatives as antimalarial agents and anti-tuberculosis agents.

InChI:InChI=1/C10H20N2O3/c1-10(2,3)15-9(14)12-5-4-11-8(6-12)7-13/h8,11,13H,4-7H2,1-3H3/t8-/m1/s1

Upstream product

• 173774-50-0 N-Boc-piperazine-2-amidoanhydride 

Downstream Products

• 278788-67-3 (R)-tert-butyl 3-(hydroxymethyl)-4-methylpiperazine-1-carboxylate 
• 1426073-09-7 (3R,9aS)-3-(3-cyano-4-fluoro-2-methyl-phenyl)-3-hydroxy-hexahydro-pyrazino[2,1-c][ 1,4]oxazine-8-carboxylic acid tert-butyl ester 
• 1443737-21-0 tert-butyl (3R)-4-[2-(4-cyano-3-methoxyphenyl)-2-hydroxyethyl]-3-(hydroxymethyl)piperazine-1-carboxylate 

Relevant articles and documents

FARNESYL PROTEIN TRANSFERASE INHIBITORS

Disclosed are compounds of formula (1.0), wherein R represents a cyclic moiety to which is bound an imodazolylalkyl group; R represents a carbamate, urea, amide or sulfonamide group; and the remaining substituents are as defined herein. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.