27913-58-2

Basic information

• Product Name: 4-(P-IODOPHENYL)BUTYRIC ACID
• Synonyms: 4-Iodobenzenebutanoic acid;4-(p-Iodophenyl)butyric acid >=98%;4-(P-IODOPHENYL)BUTYRIC ACID
• CAS NO: 27913-58-2
• Molecular Formula: C₁₀H₁₁IO₂
• Molecular Weight: 290.1
• Product Categories: C10;Carbonyl Compounds;Carboxylic Acids;Building Blocks;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis;Organic Building Blocks
• Mol File: 27913-58-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 89-89.5 °C
• Boiling Point: 351°C at 760 mmHg
• Flash Point: 166.1°C
• Appearance: /
• Density: 1.686g/cm³
• Vapor Pressure: 1.58E-05mmHg at 25°C
• Refractive Index: 1.608
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Sparingly), Methanol (Slightly)
• PKA: 4.74±0.10(Predicted)
• CAS DataBase Reference: 4-(P-IODOPHENYL)BUTYRIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(P-IODOPHENYL)BUTYRIC ACID(27913-58-2)
• EPA Substance Registry System: 4-(P-IODOPHENYL)BUTYRIC ACID(27913-58-2)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 27913-58-2(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 27913-58-2 differently. You can refer to the following data:
1. 4-(p-Iodophenyl)butyric Acid is a reactant involved in the synthesis of meta- and paracyclophanes containing unsaturated amino acids and intramolecular Friedel-Crafts reactions for synthesis of 1-tetralones.
2. Reactant involved in:? ;Synthesis of meta- and paracyclophanes containing unsaturated amino acids1? ;Intramolecular Friedel-Crafts reactions for synthesis of 1-tetralones2Involved in investigations of pharmacological activity pertaining to:? ;Apoptosis, proliferation, and histon deacetylase activity in human colorectal cancer cells3,4? ;Portable albumin binders for extending the half-life of contrast agents5

InChI:InChI=1/C10H11IO2/c11-9-6-4-8(5-7-9)2-1-3-10(12)13/h4-7H,1-3H2,(H,12,13)

Upstream product

• 1821-12-1 4-Phenylbutyric acid 
• 64-19-7 acetic acid 
• 589-87-7 1,4-bromoiodobenzene 
• 124-38-9 carbon dioxide 
• 1334204-41-9 C₁₇H₂₄BI 
• 194146-02-6 4-(4-iodophenyl)-4-oxobutanoic acid 

Downstream Products

• 145485-31-0 7-iodo-1-tetralone 
• 859169-88-3 4-(4-bromophenyl)butanoic acid pinacol ester 
• 1052138-82-5 methanesulfonic acid 4-(4-iodophenyl)butyl ester 
• 1052138-90-5 4-(4-morpholin-4-yl-phenyl)butylamine 
• 1052138-86-9 4-[4-(4-azidobutyl)phenyl]morpholine 
• 1052120-09-8 C₅₄H₉₄N₄O₁₄ 

Relevant articles and documents

THIOAMIDE-CONTAINING COMPOSITIONS AND METHODS OF USE THEREOF

Provided herein are compositions and methods for preparing albumin-targeting moieties that feature a thioamide linkage. Methods to use the albumin targeting molecules to generate drugs with improved in vivo pharmacodynamics and biodistribution are described. Therapeutic compounds incorporating these thioamide linked albumin-targeting moieties are disclosed.

Synthesis of new ferrocene derivatives with rod-like structure

The Suzuki-Miyaura cross-coupling of tris(4-ferrocenylphenyl)- and tris[4-(2-ferrocenylethynyl)phenyl]boroxines with functionalized iodoarenes gives new ferrocene derivatives of rod-like structure.

Design and synthesis of conformationally constrained analogues of cis-cinnamic acid and evaluation of their plant growth inhibitory activity

1-O-cis-Cinnamoyl-β-d-glucopyranose is known to be one of the most potent allelochemical candidates and was isolated from Spiraea thunbergii Sieb by Hiradate et al. (2004), who suggested that it derived its strong inhibitory activity from cis-cinnamic acid, which is crucial for phytotoxicity. In this study, key structural features and substituent effects of cis-cinnamic acid (cis-CA) on lettuce root growth inhibition was investigated. These structure-activity relationship studies indicated the importance of the spatial relationship of the aromatic ring and carboxylic acid moieties. In this context, conformationally constrained cis-CA analogues, in which the aromatic ring and cis-olefin were connected by a carbon bridge, were designed, synthesized, and evaluated as plant growth inhibitors. The results of the present study demonstrated that the inhibitory activities of the five-membered and six-membered bridged compounds were enhanced, up to 0.27 μM, and were ten times higher than cis-CA, while the potency of the other compounds was reduced.