27918-36-1

Basic information

• Product Name: 4'-Methoxy-2-(methylsulphonyl)acetophenone
• Synonyms: 1-(4-Methoxyphenyl)-2-(methylsulphonyl)-1-ethanone;4'-Methoxy-2-(methylsulphonyl)acetophenone;1-(4-Methoxyphenyl)-2-(methylsulphonyl)-1-ethan-1-one
• CAS NO: 27918-36-1
• Molecular Formula: C₁₀H₁₂O₄S
• Molecular Weight: 228.26488
• Mol File: 27918-36-1.mol
• Article Data: 10

Chemical Properties

• Melting Point: 136-137
• Boiling Point: 462.9°Cat760mmHg
• Flash Point: 233.8°C
• Appearance: /
• Density: 1.25g/cm³
• Vapor Pressure: 9.5E-09mmHg at 25°C
• Refractive Index: 1.525
• CAS DataBase Reference: 4'-Methoxy-2-(methylsulphonyl)acetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-Methoxy-2-(methylsulphonyl)acetophenone(27918-36-1)
• EPA Substance Registry System: 4'-Methoxy-2-(methylsulphonyl)acetophenone(27918-36-1)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 27918-36-1(Hazardous Substances Data)

Usage

General Description

4'-Methoxy-2-(methylsulphonyl)acetophenone, also known as p-methoxy-α-(methylsulphonyl)acetophenone, is a chemical compound with the molecular formula C10H12O3S. It is a white to off-white solid that is commonly used as a fragrance ingredient in cosmetic and personal care products. It is also a key intermediate in the synthesis of pharmaceuticals and agrochemicals. The compound is known for its strong and sweet odor, and it is often used in perfumes and air fresheners. Additionally, it exhibits antimicrobial and insecticidal properties, making it a versatile compound with multiple industrial applications.

InChI:InChI=1/C10H12O4S/c1-14-9-5-3-8(4-6-9)10(11)7-15(2,12)13/h3-6H,7H2,1-2H3

Upstream product

• 20277-69-4 sodium methansulfinate 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 93624-01-2 O-ethyl S-2-(4-methoxyphenyl)-2-oxoethyl carbonodithioate 
• 67-68-5 dimethyl sulfoxide 
• 67-71-0 dimethylsulfone 
• 121-98-2 methyl 4-methoxybenzoate 
• 637-69-4 4-Methoxystyrene 
• 75-75-2 methanesulfonic acid 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 100-09-4 4-methoxybenzoic acid 
• 55991-65-6 [1-(4-methoxyphenyl)vinyloxy]trimethylsilane 
• 124-63-0 methanesulfonyl chloride 
• 10364-93-9 1-(4-methoxybenzoyl)-imidazole 
• 94-30-4 ethyl 4-methoxybenzoate 

Downstream Products

• 17171-17-4 4'-methoxy-3-methylbiphenyl 
• 1599463-28-1 (Z)-N-(1-(4-methoxyphenyl)-2-(methylsulfonyl)vinyl)acetamide 

Relevant articles and documents

Synthesis of β-ketosulfone derivatives as new non-cytotoxic urease inhibitors in vitro

Background: Peptic ulcer and urolithiasis are largely due to infection caused by urease-producing bacteria. Therefore, the discovery of urease inhibitors is an important area of medicinal chemistry research. Objective: The main aim of the work was to identify novel urease inhibitors with no cytotoxicity. Method: During the current study, a series of β-ketosulfones 1-26 was synthesized in two steps and evaluated for their in vitro urease inhibition potential. Results: Out of twenty-six compounds, seventeen have shown good to significant urease inhibitory activity with IC50 values ranging between 49.93-351.46 μM, in comparison to standard thiourea (IC50 = 21 ± 0.11 μM). Moreover, all compounds found to be non-cytotoxic against normal 3T3 cell line. Conclusion: This study has identified β-ketosulfones as novel and non-cytotoxic urease inhibitors.

Facile Synthesis of β-Keto Sulfones Employing Fenton's Reagent in DMSO

A new facile method for the synthesis of β-keto sulfones employing xanthates, DMSO, and Fenton's reagent is described. The reaction proceeds under very mild conditions providing a cost-effective straightforward approach to various β-keto sulfones in high yields.

CO/O2 assisted oxidative carbon-carbon and carbon-heteroatom bond cleavage for the synthesis of oxosulfonates from DMSO and olefins

Selective carbon-carbon and carbon-heteroatom bond cleavage was achieved in a one reaction system. With this strategy a novel Pd/Cu-catalyzed aerobic oxidative oxosulfonation of olefins with DMSO has been developed. Preliminary mechanistic investigations indicated that CO/O2 assisted the bond cleavage and the leaving groups from the starting materials were trapped by O2 and underwent a hydroxylation process.