279227-01-9Relevant articles and documents
Synthesis and biological activity of new functionalized epothilones for prodrug design and tumor targeting
Dietrich, Silvia Anthoine,Riediker, Linda,Gertsch, Juerg,Altmann, Karl-Heinz
, p. 136 - 139 (2011/07/31)
Epothilones are potent antiproliferative agents, which have served as successful lead structures for anticancer drug discovery. However, their therapeutic efficacy would benefit greatly from an increase in their selectivity for tumor cells, which may be a
INHIBITORS OF HISTONE DEACETYLASE
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Page/Page column 252, (2010/02/11)
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.