27958-77-6

Basic information

• Product Name: 3-AMINO-N,N-DIMETHYLBENZYLAMINE
• Synonyms: 3-DIMETHYLAMINOMETHYL-ANILINE;3-AMINO-N,N-DIMETHYLBENZYLAMINE;Benzenemethanamine, 3-amino-N,N-dimethyl- (9CI);Aminobenzyldimethylamin (Isomerengemisch);3-AMINOBENZYL-N,N-DIMETHYLAMINE;3-Amino-N,N-dimethylbenzenemethanamine;Einecs 248-747-3;3-Amino-N,N-dimethylbenzylamin ,98%
• CAS NO: 27958-77-6
• Molecular Formula: C₉H₁₄N₂
• Molecular Weight: 150.22
• EINECS: 248-747-3
• Product Categories: AMINEPRIMARY
• Mol File: 27958-77-6.mol
• Article Data: 17

Chemical Properties

• Melting Point: 44-46 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 235.7 °C at 760 mmHg
• Flash Point: 87.5 °C
• Appearance: /
• Density: 1.013 g/cm³
• Vapor Pressure: 0.0494mmHg at 25°C
• Refractive Index: 1.566
• Storage Temp.: 2-8°C
• PKA: 8.92±0.28(Predicted)
• CAS DataBase Reference: 3-AMINO-N,N-DIMETHYLBENZYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-N,N-DIMETHYLBENZYLAMINE(27958-77-6)
• EPA Substance Registry System: 3-AMINO-N,N-DIMETHYLBENZYLAMINE(27958-77-6)

Safety Data

• Hazardous Substances Data: 27958-77-6(Hazardous Substances Data)

Usage

Uses

3-amino-n,n-dimethylbenzylamine is used as a reagent in the preparation of amino-triazole-carboxamide derivatives for use in Trypanosoma cruzi.

InChI:InChI=1/C9H14N2/c1-11(2)7-8-4-3-5-9(10)6-8/h3-6H,7,10H2,1-2H3

Upstream product

• 15184-95-9 N-(3-nitrophenylmethyl)dimethylamine 
• 3958-57-4 1-bromomethyl-3-nitrobenzene 
• 99-61-6 3-nitro-benzaldehyde 
• 121-90-4 m-nitrobenzoic acid chloride 
• 619-23-8 3-Nitrobenzyl chloride 

Downstream Products

• 4280-12-0 N-(3-Dimethylaminomethyl-phenyl)-2-[(E)-hydroxyimino]-acetamide 
• 697308-48-8 4-(4-chlorophenyl)-N-[(1R,2S)-1-[({3-[(dimethylamino)methyl]phenyl}amino)carbonyl]-2-(1H-indol-3-yl)propyl]piperazine-1-carboxamide 
• 872511-33-6 N-(3-dimethylaminomethyl-phenyl)-N'-methyl-pyrimidine-4,6-diamine 
• 503183-48-0 4-[(3-dimethylaminomethylphenyl)hydrazono]-4H-pyrazole-3,5-diamine 
• 928789-40-6 2-(3-Dimethylaminomethyl-phenylamino)-8-indan-5-yl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester 
• 941318-47-4 4-[2-(3-aminophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-{3-[(dimethylamino)methyl]phenyl}-2-pyrimidinamine 
• 1403819-30-6 N-(3-((dimethylamino)methyl)phenyl)-5-(2-fluorophenyl)-1H-pyrazolo[4,3-d]pyrimidin-7-amine 
• 1403819-10-2 N-(3-((dimethylamino)methyl)phenyl)-5-(thiophen-2-yl)-1H-pyrazolo[4,3-d]pyrimidin-7-amine 
• 850450-20-3 N-{3-[7-(3-dimethylaminomethyl-phenylamino)-1-methyl-2-oxo-1,2-dihydro-[1,6]naphthyridin-3-yl]-4-methyl-phenyl}-3-trifluoromethyl-benzamide 
• 1038550-44-5 N-[3-(3-dimethylaminomethyl-phenylcarbamoyl)-benzyl]-3,4-dimethoxy-benzamide 

Relevant articles and documents

WEE1 KINASE INHIBITORS AND METHODS OF TREATING CANCER USING THE SAME

A compound, or a pharmaceutically acceptable salts or prodrugs thereof, having the chemical structure (I) and methods of using these compounds to inhibit WEE1 kinase and treat cancer in a subject.

Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 1: High-Throughput Screening and Preliminary Exploration

Lysine specific demethylase 1 KDM1A (LSD1) regulates histone methylation and it is increasingly recognized as a potential therapeutic target in oncology. We report on a high-throughput screening campaign performed on KDM1A/CoREST, using a time-resolved fluorescence resonance energy transfer (TR-FRET) technology, to identify reversible inhibitors. The screening led to 115 hits for which we determined biochemical IC50, thus identifying four chemical series. After data analysis, we have prioritized the chemical series of N-phenyl-4H-thieno[3, 2-b]pyrrole-5-carboxamide for which we obtained X-ray structures of the most potent hit (compound 19, IC50 = 2.9 μM) in complex with the enzyme. Initial expansion of this chemical class, both modifying core structure and decorating benzamide moiety, was directed toward the definition of the moieties responsible for the interaction with the enzyme. Preliminary optimization led to compound 90, which inhibited the enzyme with a submicromolar IC50 (0.162 μM), capable of inhibiting the target in cells.

Hydrogenation of (N,N-disubstituted aminomethyl)nitrobenzenes to (N,N-disubstituted aminomethyl)anilines catalyzed by palladium-nickel bimetallic nanoparticles

Since palladium-catalysts have strong abilities for both hydrogenation of nitro-group and hydrogenolysis of benzylamine, they have a much lower chemoselectivity for the hydrogenation of (N,N-disubstituted aminomethyl)nitrobenzenes. In this article, component stable Pd-Ni bimetallic nanoparticles were prepared by simply heating RANEY-Ni and Na2PdCl4 together in water. They demonstrated novel synergistic effects when they were used as a bimetallic catalyst, by which a highly efficient and chemoselective hydrogenation of (N,N-disubstituted aminomethyl)nitrobenzenes to (N,N-disubstituted aminomethyl)anilines was achieved.