28001-33-4

Basic information

• Product Name: 1-CYCLOPROPYL-PYRROLE-2,5-DIONE
• Synonyms: 1-CYCLOPROPYL-PYRROLE-2,5-DIONE;1-CYCLOPROPYL-1H-PYRROLE-2,5-DIONE;1-cyclopropyl-3-pyrroline-2,5-quinone
• CAS NO: 28001-33-4
• Molecular Formula: C₇H₇NO₂
• Molecular Weight: 137.14
• Mol File: 28001-33-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 54-56 °C
• Boiling Point: 248.3°Cat760mmHg
• Flash Point: 114.2°C
• Appearance: /
• Density: 1.475g/cm³
• Vapor Pressure: 0.0245mmHg at 25°C
• Refractive Index: 1.646
• PKA: -2.24±0.20(Predicted)
• CAS DataBase Reference: 1-CYCLOPROPYL-PYRROLE-2,5-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CYCLOPROPYL-PYRROLE-2,5-DIONE(28001-33-4)
• EPA Substance Registry System: 1-CYCLOPROPYL-PYRROLE-2,5-DIONE(28001-33-4)

Safety Data

• Hazardous Substances Data: 28001-33-4(Hazardous Substances Data)

Usage

Molecular structure

A heterocyclic compound consisting of a pyrrole ring (a five-membered ring with one nitrogen atom) and a cyclopropyl group (a three-carbon ring with a single bond between two of the carbon atoms), with carbonyl groups (C=O) attached at the 2 and 5 positions.

Unique properties

1-Cyclopropyl-pyrrole-2,5-dione has a unique structure that makes it useful in various chemical reactions and organic synthesis.

Antioxidant properties

It has been studied for its potential antioxidant properties, which could help prevent or slow down the oxidation of other molecules.

Anticancer properties

The compound has been investigated for its potential anticancer properties, as it may be able to inhibit the growth or spread of cancer cells.

Enzyme inhibition

1-Cyclopropyl-pyrrole-2,5-dione has been shown to inhibit certain enzymes, which could have potential applications in the development of new drugs.

Pharmaceutical and agrochemical development

The compound has been investigated for its potential use in the development of new pharmaceuticals and agrochemicals, due to its diverse range of properties and potential applications.

InChI:InChI=1/C7H7NO2/c9-6-3-4-7(10)8(6)5-1-2-5/h3-5H,1-2H2

Upstream product

• 108-31-6 maleic anhydride 
• 765-30-0 Cyclopropylamine 
• 79-37-8 oxalyl dichloride 

Relevant articles and documents

The discovery, design and synthesis of potent agonists of adenylyl cyclase type 2 by virtual screening combining biological evaluation

Adenylate cyclases (ACs), play a critical role in the conversion of adenosine triphosphate (ATP) into the second messenger cyclic adenosine monophosphate (cAMP). Studies have indicated that adenylyl cyclase type 2 (AC2) is potential drug target for many diseases, however, up to now, there is no AC2-selective agonist reported. In this research, docking-based virtual screening with the combination of cell-based biological assays have been performed for discovering novel potent and selective AC2 agonists. Virtual screening disclosed a novel hit compound 8 as an AC2 agonist with EC50 value of 8.10 μM on recombinant human hAC2 + HEK293 cells. The SAR (structure activity relationship) based on the derivatives of compound 8 was further explored on recombinant AC2 cells and compound 73 was found to be the most active agonist with the EC50 of 90 nM, which is 160-fold more potent than the reported agonist Forskolin and could selectively activate AC2 to inhibit the expression of Interleukin-6. The discovery of a new class of AC2-selective agonists would provide a novel chemical probe to study the physiological function of AC2.

PHTHALIMIDE DERIVATIVES AS MODULATORS OF WNT PATHWAY

The present invention relates to compounds of formula (I), [Formula should be inserted here] pharmaceutically acceptable salts, solvates and polymorphs thereof, including all tautomers and stereoisomers thereof, wherein R1 is alkyl; alkoxy-alky