28122-82-9

Basic information

• Product Name: S-phenyl 4-chlorobenzenecarbothioate
• CAS NO: 28122-82-9
• Molecular Formula: C₁₃H₉ClOS
• Molecular Weight: 248.728
• Mol File: 28122-82-9.mol
• Article Data: 28

Chemical Properties

• Boiling Point: 357.8°C at 760 mmHg
• Flash Point: 170.2°C
• Density: 1.31g/cm³
• Vapor Pressure: 2.66E-05mmHg at 25°C
• Refractive Index: 1.65
• CAS DataBase Reference: S-phenyl 4-chlorobenzenecarbothioate(CAS DataBase Reference)
• NIST Chemistry Reference: S-phenyl 4-chlorobenzenecarbothioate(28122-82-9)
• EPA Substance Registry System: S-phenyl 4-chlorobenzenecarbothioate(28122-82-9)

Safety Data

• Hazardous Substances Data: 28122-82-9(Hazardous Substances Data)

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 108-98-5 thiophenol 
• 882-33-7 diphenyldisulfane 
• 790-41-0 4-chlorobenzoic anhydride 
• 536-40-3 4-chlorobenzoic acid hydrazide 
• 591-50-4 iodobenzene 
• 7099-88-9 4-chlorophenylglyoxylic acid 
• 106-39-8 bromochlorobenzene 
• 82102-37-2 9-methyl-9H-fluorene-9-carbonyl chloride 
• 873-76-7 para-Chlorobenzyl alcohol 
• 637-87-6 1-Chloro-4-iodobenzene 
• 74-11-3 para-chlorobenzoic acid 
• 201230-82-2 carbon monoxide 
• 5285-87-0 phenyl thiocyanate 

Downstream Products

• 53451-90-4 phenyl 4-trifluoromethylphenyl sulfide 
• 1889-71-0 4'-chloro-2-phenylacetophenone 
• 13343-26-5 phenyl p-chlorophenyl sulfide 
• 134-85-0 4-chlorobenzophenone 
• 62810-38-2 4-chlorophenyl 3-nitrophenyl ketone 
• 35256-82-7 (p-chlorophenyl)(m-methylphenyl)methanone 
• 882-33-7 diphenyldisulfane 
• 98-11-3 benzenesulfonic acid 
• 74-11-3 para-chlorobenzoic acid 
• 6833-15-4 4-chlorobenzanilide 
• 4018-82-0 4-chloro-N-(4-methoxyphenyl)benzamide 
• 39193-06-1 4,4'-dichlorobenzanilide 
• 2447-95-2 4-chloro-N-(4-tolyl)benzamide 
• 20849-33-6 phenyl p-chlorobenzenedithiocarboxylate 

Relevant articles and documents

Rh(I)-Catalyzed Intramolecular Decarbonylation of Thioesters

Decarbonylative synthesis of thioethers from thioesters proceeds in the presence of a catalytic amount of [Rh(cod)Cl]2 (2 mol %). The protocol represents the first Rh-catalyzed decarbonylative thioetherification of thioesters to yield valuable thioethers. Notable features include the absence of phosphine ligands, inorganic bases, and other additives and excellent group tolerance to aryl chlorides and bromides that are problematic using other metals to promote decarbonylation. Gram scale synthesis, late-stage pharmaceutical derivatization, and orthogonal site-selective cross-couplings by C-S/C-Br cleavage are reported.

Cu-Catalyzed Oxidative Thioesterification of Aroylhydrazides with Disulfides

An alternative thioesterification reaction via copper-catalyzed oxidative coupling of readily available aroylhydrazides with disulfides is developed, in which oxidative expulsion of N2 overcomes the activation barrier between the carboxylic acid derivativ

Fukuyama Cross-Coupling Approach to Isoprekinamycin: Discovery of the Highly Active and Bench-Stable Palladium Precatalyst POxAP

An efficient and user-friendly palladium(II) precatalyst, POxAP (post-oxidative-addition precatalyst), was identified for use in Fukuyama cross-coupling reactions. Suitable for storage under air, the POxAP precatalyst allowed reaction between thioesters and organozinc reagents with turnover numbers of ～90000. A series of 23 ketones were obtained with yields ranging from 53 to 99%. As proof of efficacy, an alternative approach was developed for the synthesis of a key precursor of the natural product isoprekinamycin.