28314-83-2

Basic information

• Product Name: 5-BroMo-2,4-difluoro-benzoic Acid
• Synonyms: 3-BroMo-4,6-difluorobenzoic Acid;EOS-62056;28314-83-2
• CAS NO: 28314-83-2
• Molecular Formula: C₇H₃BrF₂O₂
• Molecular Weight: 236.9983264
• Mol File: 28314-83-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 148-150 °C
• Boiling Point: 287.1±40.0 °C(Predicted)
• Appearance: /
• Density: 1.872±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Dimethyl Sulfoxide, Methanol, Water
• PKA: 2.82±0.10(Predicted)
• CAS DataBase Reference: 5-BroMo-2,4-difluoro-benzoic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BroMo-2,4-difluoro-benzoic Acid(28314-83-2)
• EPA Substance Registry System: 5-BroMo-2,4-difluoro-benzoic Acid(28314-83-2)

Safety Data

• Hazardous Substances Data: 28314-83-2(Hazardous Substances Data)

Usage

General Description

5-Bromo-2,4-difluoro-benzoic acid is a chemical compound with the molecular formula C7H3BrF2O2. It is a derivative of benzoic acid, containing bromine and fluorine atoms. 5-BroMo-2,4-difluoro-benzoic Acid is primarily used in the field of organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. It is also employed as a building block for the synthesis of various other compounds. Additionally, it may have potential applications in the fields of materials science and medicinal chemistry. The compound's properties and reactivity make it a valuable component in the development of new chemical compounds and materials.

Upstream product

• 651027-03-1 (3-bromo-2,6-difluorophenyl)triethylsilane 
• 651027-02-0 1-triethylsilyl-2,6-difluorobenzene 
• 372-18-9 1,3-Difluorobenzene 
• 651027-08-6 3-bromo-4,6-difluoro-5-(triethylsilyl)benzoic acid 
• 1583-58-0 2,4-difluoro-benzoic acid 

Downstream Products

• 934161-52-1 6-bromo-1-((S)-1-tert-butyldimethylsilyloxymethyl-2-methylpropyl)-7-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester 
• 697761-98-1 elvitegravir 
• 869893-92-5 6-(3-chloro-2-fluorobenzyl)-7-fluoro-1-((S)-1-hydroxymethyl-2-methylprop-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 953803-84-4 ethyl 6-bromo-4-chloro-7-fluoroquinoline-3-carboxylate 

Relevant articles and documents

Preparation method of high-purity 5-bromo-2,4-difluorobenzoic acid

The invention discloses a preparation method of high-purity 5- bromine-2,4-difluorobenzoic acid, and belongs to the technical field of synthesis of pharmaceutical and chemical intermediates. Accordingto the preparation method, 2,4-difluorobenzoic acid is reacted with a brominating reagent in sulfuric acid, after the reaction is terminated, the reaction product is esterified with alcohol, rectification and purification is carried out, and treatments such as hydrolysis, acidification and the like are carried out to obtain the high-purity of 5-bromo-2,4-difluorobenzoic acid. According to the preparation method, a solid crude product of 5-bromo-2,4-difluorobenzoic acid is esterified into a liquid, the impurity 3,5-dibromo-2,4-difluorobenzoic acid is separated by distillation, and then hydrolysis is carried out to obtain acid, so that the purity of the product can reach more than 99.5% to meet the requirements of high-quality pharmaceutical intermediates, and the yield is also improved toa certain extent to bring benefit to reduce the production cost and reduce the environmental pollution.

ANTIDIABETIC TRICYCLIC COMPOUNDS

Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

Synthesis and Radiolabelling of a Novel Thymidine Analogue for Study of Tumour Proliferation

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