283159-92-2 Usage
Description
METHYL (3R)-3-AMINO-3-(4-CHLOROPHENYL)PROPANOATE is a chemical compound with the molecular formula C11H14ClNO2. It is a derivative of propanoic acid and contains an amino group and a chlorophenyl group. METHYL (3R)-3-AMINO-3-(4-CHLOROPHENYL)PROPANOATE is known for its role as an intermediate in the synthesis of various drugs and pharmaceuticals, as well as its potential applications in organic chemistry and chemical synthesis.
Uses
Used in Pharmaceutical Industry:
METHYL (3R)-3-AMINO-3-(4-CHLOROPHENYL)PROPANOATE is used as an intermediate in the synthesis of various drugs and pharmaceuticals. Its unique structure, featuring an amino group and a chlorophenyl group, allows it to be a key component in the development of new drug candidates.
Used in Research and Development:
In the field of research and development, METHYL (3R)-3-AMINO-3-(4-CHLOROPHENYL)PROPANOATE serves as a valuable compound for the exploration and creation of novel drug candidates. Its properties make it a promising starting point for the design and synthesis of new therapeutic agents.
Used in Organic Chemistry and Chemical Synthesis:
METHYL (3R)-3-AMINO-3-(4-CHLOROPHENYL)PROPANOATE may also have potential applications in the broader field of organic chemistry and chemical synthesis. Its structural features can be utilized in various chemical reactions and processes, contributing to the advancement of chemical knowledge and the development of new compounds and materials.
Check Digit Verification of cas no
The CAS Registry Mumber 283159-92-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,8,3,1,5 and 9 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 283159-92:
(8*2)+(7*8)+(6*3)+(5*1)+(4*5)+(3*9)+(2*9)+(1*2)=162
162 % 10 = 2
So 283159-92-2 is a valid CAS Registry Number.
283159-92-2Relevant articles and documents
Stereoselective chemoenzymatic preparation of β-amino esters: Molecular modelling considerations in lipase-mediated processes and application to the synthesis of (S)-dapoxetine
Rodriguez-Mata, Maria,Garcia-Urdiales, Eduardo,Gotor-Fernandez, Vicente,Gotor, Vicente
supporting information; experimental part, p. 395 - 406 (2010/06/15)
A wide range of optically active 3-amino-3-arylpropanoic acid derivatives have been prepared by means of a stereoselective chemoenzymatic route. The key step is the kinetic resolution of the corresponding β-amino esters. Although the enzymatic acylations of the amino group with ethyl methoxyacetate showed synthetically useful enantioselectivities, the hydrolyses of the ester group catalyzed by lipase from Pseudomonas cepacia have been identified as the optimal processes concerning both activity and enantioselectivity. The enantiopreference of this lipase in these reactions has been explained, at the molecular level, by using a fragment-based approach in which the most favoured binding site for a phenyl ring and the most stable conformation of the 3-aminopropanoate core nicely match the (S)-configuration of the major products. The conversion and enantioselectivity values of the enzymatic reactions have been compared in order to understand the influence of the different substitution patterns present in the phenyl ring. This chemoenzymatic route has been successfully applied to the preparation of a valuable intermediate in the synthesis of (S)-dapoxetine, which has been chemically synthesised in excellent optical purity.
