283588-91-0Relevant articles and documents
Synthetic and theoretical investigation on the one-pot halogenation of β-amino alcohols and nucleophilic ring opening of aziridinium ions
Chen, Yunwei,Sun, Xiang,Wu, Ningjie,Li, Jingbai,Jin, Shengnan,Zhong, Yongliang,Liu, Zirui,Rogachev, Andrey,Chong, Hyun-Soon
, p. 920 - 939 (2016/01/15)
Aziridinium ions are useful reactive intermediates for the synthesis of enantiomerically enriched building blocks. However, N,N-dialkyl aziridinium ions are relatively underutilized in the synthesis of optically active molecules as compared to other three
Rearrangement of N-alkyl 1,2-amino alcohols. Synthesis of (S)-toliprolol and (S)-propanolol
Duthion, Béranger,Métro, Thomas-Xavier,Gomez Pardo, Domingo,Cossy, Janine
experimental part, p. 6696 - 6706 (2011/02/26)
N-alkyl 1,2-amino alcohols were rearranged stereospecifically by using TFAA/Et3N. This rearrangement has been used to synthesize N-isopropyl-3-(aryloxy)-2-hydroxypropylamines, β-adrenergic blocking agents such as (S)-toliprolol and (S)-propanolol.
Stereospecific rearrangement of β-amino alcohols catalyzed by H 2SO4
Métro, Thomas-Xavier,Pardo, Domingo Gomez,Cossy, Janine
, p. 2888 - 2890 (2008/02/12)
Highly enantioselective rearrangement of β-amino alcohols was realized by using a catalytic amount of H2SO4. Georg Thieme Verlag Stuttgart.
