2845-82-1

Basic information

• Product Name: 5-(PYRIDIN-4-YL)-1,3,4-OXADIAZOL-2(3H)-ONE
• Synonyms: 2-pyridyl-(4)-1,3,4-oxadiazolon-(5);4-oxadiazol-2-ol,5-(4-pyridinyl)-3;5-(4-pyridyl)-1,3,4-oxadiazol-2-ol;5-PYRIDIN-4-YL-3H-[1,3,4]OXADIAZOL-2-ONE;5-(PYRIDIN-4-YL)-1,3,4-OXADIAZOL-2(3H)-ONE;5-(4-Pyridinyl)-1,3,4-oxadiazol-2-ol;5-(4-Pyridyl)-1,3,4-oxadiazole-2(3H)-one
• CAS NO: 2845-82-1
• Molecular Formula: C₇H₅N₃O₂
• Molecular Weight: 163.13
• Mol File: 2845-82-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 306.42°C (rough estimate)
• Flash Point: °C
• Appearance: /
• Density: 1.3943 (rough estimate)
• Refractive Index: 1.6500 (estimate)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-(PYRIDIN-4-YL)-1,3,4-OXADIAZOL-2(3H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(PYRIDIN-4-YL)-1,3,4-OXADIAZOL-2(3H)-ONE(2845-82-1)
• EPA Substance Registry System: 5-(PYRIDIN-4-YL)-1,3,4-OXADIAZOL-2(3H)-ONE(2845-82-1)

Safety Data

• Hazardous Substances Data: 2845-82-1(Hazardous Substances Data)

Usage

General Description

5-(PYRIDIN-4-YL)-1,3,4-OXADIAZOL-2(3H)-ONE, also known as pyridine-4-yl 1,3,4-oxadiazol-2(3H)-one, is a chemical compound with the molecular formula C7H5N3O2. It is a heterocyclic compound containing a pyridine ring and an oxadiazole ring. 5-(PYRIDIN-4-YL)-1,3,4-OXADIAZOL-2(3H)-ONE is used in various research and pharmaceutical applications, including as a building block in the synthesis of biologically active molecules. Its functional groups and structural versatility make it a valuable intermediate for the development of drugs and other organic compounds. The chemical properties of 5-(PYRIDIN-4-YL)-1,3,4-OXADIAZOL-2(3H)-ONE make it a potential candidate for further investigation and development in the field of medicinal chemistry and drug discovery.

InChI:InChI=1/C7H5N3O2/c11-7-10-9-6(12-7)5-1-3-8-4-2-5/h1-4H,(H,10,11)

Upstream product

• 75-44-5 phosgene 
• 54-85-3 isoniazid 
• 106728-59-0 tert-butyl 2-(pyridin-4-ylmethylene)hydrazinecarboxylate 
• 15264-63-8 5-(4-pyridinyl)-1,3,4-oxadiazole-2-thiol 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 15264-63-8 5-(pyridin-4-yl)-1,3,4-oxadiazol-2(3H)-thione 
• 2459-09-8 4-pyridinecarboxylic acid, methyl ester 
• 872-85-5 pyridine-4-carbaldehyde 
• 7732-18-5 water 
• 108-88-3 toluene 
• 7647-01-0 hydrogenchloride 
• 2845-81-0 1-isonicotinoyl semicarbazide 
• 92-52-4 biphenyl 
• 2951-21-5 2-(methylthio)-5-(pyridin-4-yl)-1,3,4-oxadiazole 

Downstream Products

• 1174903-52-6 3-[[(4-methylbenzyl)-methyl-amino]methyl]-5-(pyridin-4-yl)-1,3,4-oxadiazol-2(3H)-one 
• 1174903-43-5 3-[[(3-chlorobenzyl)-methyl-amino]methyl]-5-(pyridin-4-yl)-1,3,4-oxadiazol-2(3H)-one 
• 1174903-42-4 3-[[(2-chlorobenzyl)-methyl-amino]methyl]-5-(pyridin-4-yl)-1,3,4-oxadiazol-2(3H)-one 
• 1174903-48-0 3-[[(4-bromobenzyl)-methyl-amino]methyl]-5-(pyridin-4-yl)-1,3,4-oxadiazol-2(3H)-one 
• 1174903-46-8 3-[[(2-bromobenzyl)-methyl-amino]methyl]-5-(pyridin-4-yl)-1,3,4-oxadiazol-2(3H)-one 
• 1174903-45-7 3-[[(2,4-dichlorobenzyl)-methyl-amino]methyl]-5-(pyridin-4-yl)-1,3,4-oxadiazol-2(3H)-one 
• 1174903-51-5 3-[[(4-fluorobenzyl)-methyl-amino]methyl]-5-(pyridin-4-yl)-1,3,4-oxadiazol-2(3H)-one 
• 1174903-49-1 3-[[(2-fluorobenzyl)-methyl-amino]methyl]-5-(pyridin-4-yl)-1,3,4-oxadiazol-2(3H)-one 
• 1174903-50-4 3-[[(3-fluorobenzyl)-methyl-amino]methyl]-5-(pyridin-4-yl)-1,3,4-oxadiazol-2(3H)-one 
• 1174903-41-3 3-[(benzyl-methyl-amino)methyl]-5-(pyridin-4-yl)-1,3,4-oxadiazol-2(3H)-one 
• 1174903-44-6 3-[[(4-chlorobenzyl)-methyl-amino]methyl]-5-(pyridin-4-yl)-1,3,4-oxadiazol-2(3H)-one 
• 15563-03-8 N-butyl-2-isonicotinoylhydrazine-1-carboxamide 

Relevant articles and documents

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Propylene oxide assisted one-pot, tandem synthesis of substituted-1,3,4- oxadiazole-2(3H)-ones in water

It has been developed for the synthesis of substituted-1,3,4-oxadiazole- 2(3H)-one derivatives via a novel one-pot, tandem procedure assisted by propylene oxide. The 5-substitued-1,3,4-oxadiazole-2(3H)-ones and 3,5-disubstitued-1,3,4-oxadiazole-2(3H)-ones were, respectively, obtained from three-component reaction of acylhydrazines, carbon disulfide, and propylene oxide, and four-component reaction of acylhydarazines, carbon disulfide, propylene oxide, and organic halides. The reactions were carried out using water as solvent in the presence of potassium phosphate to afford the expected products in good to excellent yields.

Efficient phosphonium-mediated synthesis of 2-amino-1,3,4-oxadiazoles

We present an efficient, room temperature procedure for the preparation of 2-amino-1,3,4-oxadiazoles. Oxadiazol-2-ones can be activated for SnAr substitution using phosphonium reagents (e.g., BOP). This approach provides convenient access to N,