286420-55-1Relevant articles and documents
A concise synthesis of the 6-O- and 6'-O-sulfated analogues of the sialyl Lewis X tetrasaccharide
Misra, Anup Kumar,Ding, Yili,Lowe, John B.,Hindsgaul, Ole
, p. 1505 - 1509 (2007/10/03)
The octyl glycoside of the sialyl Lewis X tetrasaccharide and its 6-O-sulfated and 6'-O-sulfated analogues were chemically synthesized in a concise manner starting from readily accessible monosaccharide intermediates. The synthesis involved formation of an orthogonally protected tetrasaccharide intermediate from which all three materials were prepared. A selective catalytic hydrogenolysis of four O-benzyl ethers in presence of a 4,6-O-benzylidene group was the key step in the synthetic scheme. (C) 2000 Elsevier Science Ltd. All rights reserved.