286459-64-1

Basic information

• Product Name: (1R,3S)-1-(m-benzyloxybenzyl)-2-pivaloyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
• Synonyms: (1R,3S)-1-(m-benzyloxybenzyl)-2-pivaloyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
• CAS NO: 286459-64-1
• Molecular Weight: 457.569
• Mol File: 286459-64-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1R,3S)-1-(m-benzyloxybenzyl)-2-pivaloyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,3S)-1-(m-benzyloxybenzyl)-2-pivaloyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid(286459-64-1)
• EPA Substance Registry System: (1R,3S)-1-(m-benzyloxybenzyl)-2-pivaloyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid(286459-64-1)

Safety Data

• Hazardous Substances Data: 286459-64-1(Hazardous Substances Data)

Upstream product

• 1700-31-8 3-benzyloxybenzyl bromide 
• 116174-79-9 (3S)-1,2,3,4-tetrahydro-2-pivaloylisoquinoline-3-carboxylic acid 
• 3282-30-2 pivaloyl chloride 
• 77497-96-2 (S)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid, phenylmethylester 
• 116174-78-8 benzyl (S)-1,2,3,4-tetrahydro-2-pivaloyl-isoquinoline-3-carboxylate 

Downstream Products

• 613232-44-3 (1R,3S)-1-(m-benzyloxybenzyl)-2-pivaloyl-Tic-(S)-Phe-OBn 
• 613232-46-5 benzyl (1R,3S)-1-(m-benzyloxybenzyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate 
• 613232-48-7 Boc-Gly-(1R,3S)-1-(m-hydroxybenzyl)Tic-OH 
• 286459-69-6 methyl Z-glycyl-(1R,3S)-1-(m-benzyloxybenzyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate 
• 613232-47-6 Boc-Gly-(1R,3S)-1-(m-benzyloxybenzyl)Tic-OBn 
• 613232-50-1 Z-Gly-(1R,3S)-1-(m-benzyloxybenzyl)Tic-Phe-OBn 

Relevant articles and documents

Synthesis of 1-(m-hydroxybenzyl)-substituted 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives as opioid peptide mimetics - Unexpected amide bond cleavages under mild conditions

N-Glycyl-(1R,3S)-1-(m-hydroxybenzyl)-1,2,3, 4-tetrahydroisoquinoline-3-carboxylic acid (Tic) was prepared as a Tyr-Tic dipeptide mimetic for exploration of its potential as a delta opioid receptor selective ligand. The compound was successfully obtained b