2867-63-2Relevant articles and documents
Generation of Acyl Radical Equivalents by Cathodic Reduction of Acyl Tributylphosphonium Ions
Maeda, Hatsuo,Maki, Toshihide,Ohmori, Hidenobu
, p. 249 - 250 (1995)
The species generated by one-electron transfer to acyl tributylphosphonium ions has proved to be potent acyl radical equivalents by the results that unsubstituted and 6-phenyl- substituted 5-hexenoic acids were transformed into cyclopentanones by the electrolysis in the presence of Bu3P in an undivided cell, although the yields were not satisfactory due to the formation of 5-hexen-1-als via further one-electron reduction of the radicals before their cyclization.
Substituted cyclopropylamines from pyridinium ylide: Complexes of pentacarbonyl tungsten and enamines
Martin-Vaca, Bianca,Durand-Reville, Thomas,Audouin, Max,Rudler, Henri
, p. 1534 - 1538 (1998)
Enamines derived from cyclic ketones react very easily with a series of pyridinium ylide complexes of tungsten pentacarbonyl (CO)5W--C(R)(H) Py+ to give either at room temperature (for R = Ph) or at 40°C (for R = alkyl) substituted cyclopropylamines as mixtures of stereoisomers.
INHIBITORS OF NOROVIRUS AND CORONAVIRUS REPLICATION
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, (2021/10/15)
Compounds of Formula (I) and methods of inhibiting the replication of viruses in a biological sample or patient, of reducing the amount of viruses in a biological sample or patient, and of treating a virus infection in a patient, comprising administering to said biological sample or patient an effective amount of a compound represented by Formula (I), a compound of Table A or B or a pharmaceutically acceptable salt thereof.
A Proton-Responsive Pyridyl(benzamide)-Functionalized NHC Ligand on Ir Complex for Alkylation of Ketones and Secondary Alcohols
Kaur, Mandeep,U Din Reshi, Noor,Patra, Kamaless,Bhattacherya, Arindom,Kunnikuruvan, Sooraj,Bera, Jitendra K.
supporting information, p. 10737 - 10748 (2021/06/15)
A Cp*Ir(III) complex (1) of a newly designed ligand L1 featuring a proton-responsive pyridyl(benzamide) appended on N-heterocyclic carbene (NHC) has been synthesized. The molecular structure of 1 reveals a dearomatized form of the ligand. The protonation of 1 with HBF4 in tetrahydrofuran gives the corresponding aromatized complex [Cp*Ir(L1H)Cl]BF4 (2). Both compounds are characterized spectroscopically and by X-ray crystallography. The protonation of 1 with acid is examined by 1H NMR and UV-vis spectra. The proton-responsive character of 1 is exploited for catalyzing α-alkylation of ketones and β-alkylation of secondary alcohols using primary alcohols as alkylating agents through hydrogen-borrowing methodology. Compound 1 is an effective catalyst for these reactions and exhibits a superior activity in comparison to a structurally similar iridium complex [Cp*Ir(L2)Cl]PF6 (3) lacking a proton-responsive pendant amide moiety. The catalytic alkylation is characterized by a wide substrate scope, low catalyst and base loadings, and a short reaction time. The catalytic efficacy of 1 is also demonstrated for the syntheses of quinoline and lactone derivatives via acceptorless dehydrogenation, and selective alkylation of two steroids, pregnenolone and testosterone. Detailed mechanistic investigations and DFT calculations substantiate the role of the proton-responsive ligand in the hydrogen-borrowing process.
Synthesis and structural characterization of facile ruthenium(II) hydrazone complexes: Efficient catalysts in α-alkylation of ketones with primary alcohols via hydrogen auto transfer
Kalaiarasi, Chinnasamy,Murugan, Kaliyappan,Vijayan, Paranthaman,Vijayapritha, Subbarayan,Viswanathamurthi, Periasamy
supporting information, (2020/08/06)
As a immersion for development of new complexes, new Ru(II) complexes (1–3) supported by benzothiazole hydrazine Schiff bases of the type [Ru(SAL-HBT)(CO)(AsPh3)2], [Ru(VAN-HBT)(CO)(AsPh3)2] and [Ru(NAP-HBT)(CO)Cl(AsPh3)2] [SAL-HBT = (salicyl((2-(benzothiazol-2yl)hydrazono)methylphenol)), VAN-HBT = 2-((2-(benzothiazol-2-yl)hydrazono)methyl)-6 methoxyphenol) and NAP-HBT = naphtyl-2-((2-(benzothiazol-2-yl)hydrazono)methyl phenol)] were synthesized. Their identities have been established by satisfactory elemental analyses, various spectroscopic techniques (IR, (1H, 13C) NMR) and also mass spectrometry. The ruthenium(II) ion exhibits a hexa coordination with distorted octahedral geometry. In complexes 1 and 2, the ligand coordinated as dianionic tridentate fashion by forming N^N donor five member and N^O donor six member chelate rings. However, in complex 3, the ligand coordinated as monoanionic bidentate fashion by forming N^N donor five-membered ring. The new ruthenium(II) carbonyl complexes were successfully applied as catalysts in α -alkylation of aliphatic and aromatic ketones with alcohols via borrowing hydrogen strategy. Various parameters such as base, solvent, temperature, time and catalyst loading on the catalytic activity were analyzed. From the results, the catalyst 1 was found to be the best catalyst for α-alkylation reaction to obtain excellent yield. The catalytic system has a broad substrate scope, which allows the synthesis of α-alkylated ketones in mild reaction conditions with low catalyst loading under air atmosphere.
