28721-08-6Relevant articles and documents
RECEPTOR ANTAGONIST, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND USAGE THEREOF
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Paragraph 0237-0238, (2021/01/14)
The present invention discloses a receptor inhibitor of formula (I), a composition comprising the same and the usage thereof.
NOVEL PROCESS FOR PREPARATION OF 10-OXO-10, 11-DIHYDRO-5H-DIBENZ [b,f]AZEPINE-5-CARBOXAMIDE (OXCARBAZEPINE) VIA INTERMEDIATE, 10-METHOXY-5H-DIBENZ[b,f] AZEPINE-5-CARBONYLCHLORIDE
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Page/Page column 8, (2008/06/13)
Novel process for preparation of 10-oxo-10, 11-dihydro-SH-dibenz[b,f] azepine-5--carboxamide (oxcarbazepine) via intermediate 10-methoxy-5H--dibenz [b,f] azepine -5 carbonyl, chloride; comprising the steps: a) Preparation of an intermediate 10-methoxy-5H-dibenz [b,f] azepine -5 carbonyl, chloride from 10-methoxyiminostillbene using bis (trichloromethyl) carbonate (BTC) with organic base such as aliphatic or aromatic tertiary amines in organic solvent b) Conversion of the intermediate to 10-methoxy-5H-dlbenz[b,f] azepine -5-- carboxamide using ammonia in organic solvent c) Formation of oxcarbazepine from step(b) using Lewis acid in an organic solvent at a temperature between 25°C - 80°C, preferably at 50°C to 70°C d) Isolation of oxcarbazepine.
Process for the preparation of oxcarbazepine
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Page/Page column 2; 7; 9, (2008/06/13)
The reaction between 10-methoxy-iminostilbene (IV) and of(trichloromethyl)carbonate affords 10-methoxy-N-chlorocarbonyliminostilbene (XVI) in high yields, then ammonolysis and subsequent hydrolysis of the enol ether provides particularly pure oxcarbazepine.