2887-35-6

Basic information

• Product Name: 5-phenyl-3-(2,4,6-trimethoxyphenyl)isoxazole
• Synonyms: 5-phenyl-3-(2,4,6-trimethoxyphenyl)isoxazole
• CAS NO: 2887-35-6
• Molecular Weight: 311.337
• Mol File: 2887-35-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-phenyl-3-(2,4,6-trimethoxyphenyl)isoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-phenyl-3-(2,4,6-trimethoxyphenyl)isoxazole(2887-35-6)
• EPA Substance Registry System: 5-phenyl-3-(2,4,6-trimethoxyphenyl)isoxazole(2887-35-6)

Safety Data

• Hazardous Substances Data: 2887-35-6(Hazardous Substances Data)

Upstream product

• 145629-35-2 (E)-3-phenyl-1-(2, 4, 6-trimethoxyphenyl)prop-2-en-1-one 
• 100-52-7 benzaldehyde 
• 832-58-6 1-(2,4,6-trimethoxyphenyl)ethanone 

Relevant articles and documents

Design, synthesis and biological evaluation of 3,5-diaryl isoxazole derivatives as potential anticancer agents

The present study was carried out in the attempt to synthesize a new class of potential anticancer agents comprising eleven compounds (24–34) sharing the 3,5-diarylisoxazole as a core. The chemical structure of the new synthesized compounds was established by IR, 1H NMR, 13C NMR and elemental analysis. Their biological potential towards prostate cancer was evaluated by using cancer PC3 cells and non-tumorigenic PNT1a cells. Interestingly, compound 26 distinguished from others with a quite high selectivity value that is comparable to 5-FU. The binding mode of 26 towards Ribosomal protein S6 kinase beta-1 (S6K1) was investigated at a molecular level of detail by employing docking simulations based on GLIDE standard precision as well as MM-GBSA calculations.