28968-07-2

Basic information

• Product Name: CLIDANAC
• Synonyms: Clidanac
• CAS NO: 28968-07-2
• Molecular Formula: C16H19ClO2
• Molecular Weight: 278.777
• Mol File: 28968-07-2.mol
• Article Data: 6

Chemical Properties

• Melting Point: 150.5-152.5°
• Boiling Point: 389.8°C (rough estimate)
• Appearance: /
• Density: 1.0855 (rough estimate)
• Refractive Index: 1.5330 (estimate)
• CAS DataBase Reference: CLIDANAC(CAS DataBase Reference)
• NIST Chemistry Reference: CLIDANAC(28968-07-2)
• EPA Substance Registry System: CLIDANAC(28968-07-2)

Safety Data

• Hazardous Substances Data: 28968-07-2(Hazardous Substances Data)

Usage

Description

CLIDANAC, also known as Clidanac, is a non-steroidal anti-inflammatory drug (NSAID) that belongs to the oxicam class. It is characterized by its potent anti-inflammatory, analgesic, and antipyretic properties. CLIDANAC works by inhibiting the cyclooxygenase (COX) enzymes, which are responsible for the production of prostaglandins that cause inflammation and pain. Its unique chemical structure allows it to be used in various applications across different industries.

Uses

Used in Pharmaceutical Industry:
CLIDANAC is used as an anti-inflammatory agent for the treatment of various conditions characterized by inflammation, pain, and fever. Its potent action on COX enzymes makes it an effective choice for managing symptoms associated with conditions such as arthritis, tendinitis, and musculoskeletal disorders.
Used in Dermatology:
CLIDANAC is used as a replacement for retinol in skin treatment, offering an alternative option for patients who may experience adverse effects or sensitivities to retinol. Its anti-inflammatory properties make it suitable for treating skin conditions such as acne, rosacea, and eczema.
Used in Gastroenterology:
CLIDANAC is used to treat anal fissures, which are small tears in the lining of the anus that can cause severe pain and bleeding. Its analgesic and anti-inflammatory actions help to reduce pain, inflammation, and promote healing of the affected area.
Used in Drug Development:
CLIDANAC is used as a preparation of ester prodrugs of NSAIDs, which are designed to improve the drug's pharmacokinetic properties, such as solubility, absorption, and bioavailability. These prodrugs are then metabolized in the body to release the active drug, providing a more effective and safer treatment option for patients.

Upstream product

• 31962-05-7 5-Cyclohexyl-1-indancarboxylic acid 
• 31962-03-5 (3-chloro-4-cyclohexyl-phenyl)-succinic acid anhydride 
• 28968-04-9 (+/-)-5-Cyclohexyl-3-oxo-1-indancarbonsaeure 
• 36414-05-8 (4-cyclohexyl-phenyl)-succinic acid anhydride 
• 31861-70-8 3-Oxo-5-cyclohexyl-6-chlorindan-1-carbonsaeure 
• 28968-08-3 (1R)-(+)-5-Cyclohexylindan-1-carbonsaeure 
• 38913-05-2 α-Cyan-4-cyclohexylzimtsaeure-aethylester 
• 34177-35-0 dimethyl 2-(4-cyclohexylphenyl)succinate 
• 52487-42-0 5-Cyclohexyl-1-indancarbonitrile 
• 38240-91-4 5-Cyclohexyl-1-indanone 
• 27634-89-5 4-cyclohexylbenzaldehyde 

Downstream Products

• 34159-13-2 6-Chlor-5-cyclohexylindan-1-carbonsaeureamid 
• 34177-64-5 1-Methyl-5-cyclohexyl-6-chlorindan-1-carbonsaeure 
• 41695-58-3 Acetic acid 2-(6-chloro-5-cyclohexyl-indan-1-yl)-2-oxo-ethyl ester 
• 34867-38-4 6-Chloro-5-cyclohexyl-1-indancarbonitrile 
• 52802-53-6 1-Acetyl-6-chlor-5-cyclohexylindan 
• 52802-52-5 1-(6-Chloro-5-cyclohexyl-indan-1-yl)-2-diazo-ethanone 

Relevant articles and documents

A NEW SYNTHESIS OF SOME NON-STEROIDAL ANTI-INFLAMMATORY AGENTS VIA CYANOPHOSPHATES

A simple and convenient procedure for the syntheses of some non-steroidal anti-inflammatory agents, ibuprofen, rac-naproxen, clidanac and loxoprofen, is described.

1-Indancarboxylic acids. I. Electrophilic substitution reactions of 1-indancarboxylic acid and synthesis of 6-substituted 1-indancarboxylic acids as potential antiinflammatory agents

-

5-Substituted-1-indancarboxylic acids as potential antiinflammatory agents.

-