2909-82-2

Basic information

• Product Name: 4-tert-butyl-o-toluidine
• Synonyms: 4-tert-butyl-o-toluidine
• CAS NO: 2909-82-2
• Molecular Formula: C11H17N
• Molecular Weight: 163.25938
• EINECS: 220-825-1
• Mol File: 2909-82-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 251.1°Cat760mmHg
• Flash Point: 105.7°C
• Appearance: /
• Density: 0.934g/cm³
• Vapor Pressure: 0.0209mmHg at 25°C
• Refractive Index: 1.526
• PKA: 4.78±0.10(Predicted)
• CAS DataBase Reference: 4-tert-butyl-o-toluidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-tert-butyl-o-toluidine(2909-82-2)
• EPA Substance Registry System: 4-tert-butyl-o-toluidine(2909-82-2)

Safety Data

• Hazardous Substances Data: 2909-82-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H17N/c1-8-7-9(11(2,3)4)5-6-10(8)12/h5-7H,12H2,1-4H3

Upstream product

• 13061-96-6 dihydroxy-methyl-borane 
• 103273-01-4 2-bromo-4-tert-butylaniline 
• 1075-38-3 m-t-butyltoluene 
• 823-96-1 Trimethylboroxine 
• 769-92-6 4-tert-Butylaniline 
• 95-53-4 o-toluidine 
• 115-11-7 isobutene 
• 78-83-1 2-methyl-propan-1-ol 
• 636-21-5 o-toluidine hydrochloride 

Downstream Products

• 1397706-31-8 C₁₉H₂₀N₄ 
• 409097-55-8 2-Bromo-N-(4-tert-butyl-2-methylphenyl)acetamide 
• 683223-25-8 4-(tert-butyl)-2-methylphenylisothiocyanate 
• 33691-85-9 4-(tert-butyl)-2-methylbenzoic acid 
• 71005-10-2 4-(tert-butyl)-2-methylbenzonitrile 
• 337471-08-6 acetic acid-(4-tert-butyl-2-methyl-anilide) 

Relevant articles and documents

COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CFTR

The present disclosure is directed to disclosed compounds that modulate, e.g., address underlying defects in cellular processing of CFTR activity.

Oxidative fluorination of N-arylsulfonamides

We report a late stage oxidative nucleophilic fluorination of N-arylsulfonamides, a class of compounds so far not considered as precursors to 4-fluorophenyl sulfonamides. By installing a para-positioned tert-butyl substituent on the aniline, oxidative fluorination takes place regioselectively in the presence of HF·pyridine and PIDA. This methodology has been shown to give good yields for a variety of ortho- and meta-functionalised N-arylsulfonamides and has been adapted for radiofluorination to give 4-[18F]fluorophenyl sulfonamides under carrier added conditions.