2912-98-3

Basic information

• Product Name: N-(1-PYRIDIN-4-YL-ETHYL)-HYDROXYLAMINE
• Synonyms: N-(1-PHENYL-ETHYL)-HYDROXYLAMINE;N-(1-PYRIDIN-4-YL-ETHYL)-HYDROXYLAMINE
• CAS NO: 2912-98-3
• Molecular Formula: C₈H₁₁NO
• Molecular Weight: 138.17
• Mol File: 2912-98-3.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 250.858 °C at 760 mmHg
• Flash Point: 117.221 °C
• Appearance: /
• Density: 1.061 g/cm³
• Vapor Pressure: 0.011mmHg at 25°C
• Refractive Index: 1.546
• CAS DataBase Reference: N-(1-PYRIDIN-4-YL-ETHYL)-HYDROXYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(1-PYRIDIN-4-YL-ETHYL)-HYDROXYLAMINE(2912-98-3)
• EPA Substance Registry System: N-(1-PYRIDIN-4-YL-ETHYL)-HYDROXYLAMINE(2912-98-3)

Safety Data

• Hazardous Substances Data: 2912-98-3(Hazardous Substances Data)

Usage

General Description

N-(1-Pyridin-4-yl-ethyl)-hydroxylamine is a chemical compound that is derived from hydroxylamine and has a pyridine group attached to an ethyl group. It is commonly used as a reagent in organic synthesis, particularly for the conversion of carbonyl compounds to oximes. N-(1-PYRIDIN-4-YL-ETHYL)-HYDROXYLAMINE exhibits properties of both a base and a nucleophile, making it useful in a variety of chemical reactions. It is also utilized in the pharmaceutical industry for the synthesis of various drugs and as a precursor for the preparation of other organic compounds. Additionally, N-(1-Pyridin-4-yl-ethyl)-hydroxylamine has potential applications in the field of materials science, as it can be used in the fabrication of nanostructures and functional materials.

InChI:InChI=1/C8H11NO/c1-7(9-10)8-5-3-2-4-6-8/h2-7,9-10H,1H3

Upstream product

• 20989-17-7 Phenylglycinol 
• 136386-26-0 C₇H₁₃NO₂ 
• 71-43-2 benzene 
• 613-91-2 acetophenone oxime 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 321917-76-4 (R)-N-(4-methoxybenzylidene)-1-methylbenzylamine 
• 1422542-35-5 C₁₆H₁₇NO₂ 
• 10341-75-0 (E)-1-phenylethanone oxime 
• 98-86-2 acetophenone 
• 1361044-66-7 [¹⁸O]-acetophenone oxime 
• 100-42-5 styrene 
• 2835-06-5 phenylglycin 
• 6097-58-1 ethyl 2-phenyl-2-aminoacetate 
• 346461-21-0 C₂₄H₂₃NO₅ 

Downstream Products

• 84388-95-4 N-benzylidene-1-phenylethanamine N-oxide 
• 187225-99-6 (2aS,5aR,10bS,10cR)-9-Fluoro-1-((R)-1-phenyl-ethyl)-1,2a,3,4,5,5a,10b,10c-octahydro-2,6-dioxa-1-aza-aceanthrylene 
• 187226-00-2 (2aR,5aS,10bR,10cS)-9-Fluoro-1-((R)-1-phenyl-ethyl)-1,2a,3,4,5,5a,10b,10c-octahydro-2,6-dioxa-1-aza-aceanthrylene 
• 187226-02-4 (2aR,5aS,10bS,10cS)-9-Fluoro-1-((R)-1-phenyl-ethyl)-1,2a,3,4,5,5a,10b,10c-octahydro-2,6-dioxa-1-aza-aceanthrylene 
• 187226-01-3 (2aS,5aR,10bR,10cR)-9-Fluoro-1-((R)-1-phenyl-ethyl)-1,2a,3,4,5,5a,10b,10c-octahydro-2,6-dioxa-1-aza-aceanthrylene 
• 187225-96-3 (3aS,9bR)-8-Fluoro-1-((R)-1-phenyl-ethyl)-1,3a,4,9b-tetrahydro-3H-chromeno[4,3-c]isoxazole 
• 851428-73-4 (R)-N-(α-methylbenzyl)-C-[5-methyl-2-(N-carbethoxy-allylamino)-thien-3-yl]nitrone 
• 948832-18-6 diethyl (3R,5S)-5-(hydroxymethyl)-2-[(R)-1-phenylethyl]isoxazolidinyl-3-phosphonate 
• 948832-29-9 diethyl (3R,5S)-5-(mesyloxymethyl)-2-[(R)-1-phenylethyl]isoxazolidinyl-3-phosphonate 
• 87681-48-9 (S)-2-((R)-1-Phenyl-ethyl)-isoxazolidine-5-carbaldehyde 
• 87681-48-9 (R)-2-((R)-1-Phenyl-ethyl)-isoxazolidine-5-carbaldehyde 
• 87681-45-6 [(S)-2-((R)-1-Phenyl-ethyl)-isoxazolidin-5-yl]-methanol 

Relevant articles and documents

Analogues of the Herbicide, N-Hydroxy- N-isopropyloxamate, Inhibit Mycobacterium tuberculosis Ketol-Acid Reductoisomerase and Their Prodrugs Are Promising Anti-TB Drug Leads

New drugs to treat tuberculosis (TB) are urgently needed to combat the increase in resistance observed among the current first-line and second-line treatments. Here, we propose ketol-acid reductoisomerase (KARI) as a target for anti-TB drug discovery. Twenty-two analogues of IpOHA, an inhibitor of plant KARI, were evaluated as antimycobacterial agents. The strongest inhibitor of Mycobacterium tuberculosis (Mt) KARI has a Ki value of 19.7 nM, fivefold more potent than IpOHA (Ki = 97.7 nM). This and four other potent analogues are slow- and tight-binding inhibitors of MtKARI. Three compounds were cocrystallized with Staphylococcus aureus KARI and yielded crystals that diffracted to 1.6-2.0 ? resolution. Prodrugs of these compounds possess antimycobacterial activity against H37Rv, a virulent strain of human TB, with the most active compound having an MIC90 of 2.32 ± 0.04 μM. This compound demonstrates a very favorable selectivity window and represents a highly promising lead as an anti-TB agent.

B(C6F5)3-catalyzed hydrogenation of oxime ethers without cleavage of the N-O bond

The hydrogenation of oximes and oxime ethers is usually hampered by N-O bond cleavage, hence affording amines rather than hydroxylamines. The boron Lewis acid B(C6F5)3 is found to catalyze the chemoselective hydrogenation

A simple protocol for NMR analysis of the enantiomeric purity of chiral hydroxylamines

A practically simple three-component chiral derivatization protocol for determining the enantiopurity of chiral hydroxylamines by 1H NMR spectroscopic analysis is described, involving their treatment with 2-formylphenylboronic acid and enantiopure BINOL to afford a mixture of diastereomeric nitrono-boronate esters whose ratio is an accurate reflection of the enantiopurity of the parent hydroxylamine.