2921-13-3

Basic information

• Product Name: norcarnitine
• Synonyms: norcarnitine;Butanoic acid, 4-(dimethylamino)-3-hydroxy-, (R)-;Sodium norcarnitine;(R)-4-(DiMethylaMino)-3-hydroxybutanoic Acid;L-4-(DiMethylaMino)-3-hydroxybutyric Acid;L-Norcarnitine
• CAS NO: 2921-13-3
• Molecular Formula: C6H13NO3
• Molecular Weight: 147.17232
• Mol File: 2921-13-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 292°Cat760mmHg
• Flash Point: 130.4°C
• Appearance: /
• Density: 1.155g/cm³
• Vapor Pressure: 0.000202mmHg at 25°C
• Refractive Index: 1.487
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
• CAS DataBase Reference: norcarnitine(CAS DataBase Reference)
• NIST Chemistry Reference: norcarnitine(2921-13-3)
• EPA Substance Registry System: norcarnitine(2921-13-3)

Safety Data

• Hazardous Substances Data: 2921-13-3(Hazardous Substances Data)

Usage

Uses

L-Norcarnitine is a butyric acid derivative used in the preparation of L-Carnitine (C184110).

InChI:InChI=1/C6H13NO3/c1-7(2)4-5(8)3-6(9)10/h5,8H,3-4H2,1-2H3,(H,9,10)/t5-/m1/s1

Upstream product

• 50-00-0 formaldehyd 
• 924-49-2 DL-4-amino-3-hydroxybutyric acid 
• 7013-05-0 (S)-4-amino-3-hydroxybutanoic acid 
• 7013-07-2 (R)-4-Amino-3-hydroxybutanoic acid 
• 1255078-56-8 (E)-ethyl 4-(dimethylamino)but-2-enoate hydrochloride 

Downstream Products

• 89909-98-8 (+/-)-4-Dimethylamino-3-hydroxy-buttersaeure-amid 
• 78879-70-6 (+/-)-4-Dimethylamino-butandiol-(1,3) 
• 90227-57-9 (+/-)-4-Dimethylamino-3-hydroxy-buttersaeure-aethylester 

Relevant articles and documents

METHOD OF PREPARING AN ALKYLAMINE DERIVATIVE

The present invention provides a method of preparing an alkylamine derivates which hardly generates impurities and enables mass production with high purity.

Asymmetric synthesis of (R)-(-)-carnitine

A TiCl4-promoted Mukaiyama-type aldol reaction of the ketenesilyl acetal of ethyl acetate with the lactone carbonyl of (5R,6S)-4-(benzyloxycarbonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin- 2-one (1) proceeds with a high degree of diastereoselectivity. The TBDMS-protected hemiketal thus obtained was efficiently converted into highly enantiomerically enriched (R)-(-)-carnitine by following an elimination-reduction protocol. This approach further demonstrates the utility of commercially available glycine template 1 as a potential substrate for the asymmetric synthesis of both enantiomers of carnitine.