292143-15-8Relevant articles and documents
Synthesis and structure-activity relationships of novel fungal chitin synthase inhibitors
Masubuchi, Kazunao,Taniguchi, Mikio,Umeda, Isao,Hattori, Kazuo,Suda, Hitomi,Kohchi, Yasunori,Isshiki, Yoshiaki,Sakai, Toshiya,Kohchi, Masami,Shirai, Michio,Okabe, Hisafumi,Sudoh, Masayuki,Yamazaki, Toshikazu,Shimma, Nobuo
, p. 1459 - 1462 (2000)
A novel Candida albicans chitin synthase 1 (CaChs1) inhibitor, RO-41-0986 (1) was discovered by random screening. Systematic modification led to the identification of a highly potent CaChs1 inhibitor, RO-09-3024 (2), having strong antifungal activity against Candida spp. in vitro. (C) 2000 Elsevier Science Ltd. All rights reserved.