2928-58-7

Basic information

• Product Name: [2-(4-bromophenyl)-2-oxoethyl](triphenyl)phosphonium
• CAS NO: 2928-58-7
• Molecular Formula: Br*C₂₆H₂₁BrOP
• Molecular Weight: 460.3216
• Mol File: 2928-58-7.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: [2-(4-bromophenyl)-2-oxoethyl](triphenyl)phosphonium(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(4-bromophenyl)-2-oxoethyl](triphenyl)phosphonium(2928-58-7)
• EPA Substance Registry System: [2-(4-bromophenyl)-2-oxoethyl](triphenyl)phosphonium(2928-58-7)

Safety Data

• Hazardous Substances Data: 2928-58-7(Hazardous Substances Data)

Usage

Description

[2-(4-bromophenyl)-2-oxoethyl](triphenyl)phosphonium is a phosphonium salt characterized by a phosphorus atom bonded to three phenyl groups and a bromophenyl and an oxoethyl moiety. [2-(4-bromophenyl)-2-oxoethyl](triphenyl)phosphonium is recognized for its strong nucleophilic properties and unique structural features, making it a versatile reactant in organic synthesis.

Uses

Used in Organic Synthesis:
[2-(4-bromophenyl)-2-oxoethyl](triphenyl)phosphonium is used as a reactant in organic synthesis for its strong nucleophilic properties, which facilitate various chemical reactions and contribute to the formation of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, [2-(4-bromophenyl)-2-oxoethyl](triphenyl)phosphonium is used as a building block for the synthesis of complex organic molecules with potential therapeutic applications. Its unique reactivity and structural properties make it a valuable component in the development of new pharmaceutical compounds.
Used in Material Industry:
[2-(4-bromophenyl)-2-oxoethyl](triphenyl)phosphonium is also utilized in the material industry, where its structural properties and reactivity are harnessed to create novel materials with specific characteristics for various applications.
Used in Catalyst Development:
[2-(4-bromophenyl)-2-oxoethyl](triphenyl)phosphonium has been investigated for its potential application in the development of new organic catalysts, which are essential for enhancing the efficiency and selectivity of chemical reactions in various industrial processes.

Upstream product

• 128256-27-9 2-bromo-1-phenylethanone phenylsulfonylhydrazone 
• 1777-57-7 p-bromobenzoylmethylenetriphenylphosphorane 
• 128256-29-1 C₁₄H₁₂BrClN₂O₂S 
• 99-73-0 para-bromophenacyl bromide 
• 603-35-0 triphenylphosphine 
• 99-90-1 para-bromoacetophenone 

Downstream Products

• 254453-91-3 p-(2-thienyl)benzoylmethylidenetriphenylphosphorane 
• 254453-88-8 4-(p-fluorophenyl)benzoylmethylidenetriphenylphosphorane 
• 254453-87-7 4'-methoxybiphenyl-4-ylcarbonylmethylidenetriphenylphosphorane 
• 497093-08-0 p-(p-trifluoromethylphenyl)benzoylmethylidenetriphenylphosphorane 
• 2959-60-6 1-([1,1'-biphenyl]-4-yl)-2-(triphenyl-λ⁵-phosphaneylidene)ethan-1-one 
• 868359-26-6 1-(4-bromophenyl)non-2-ene-1,8-dione 
• 22731-70-0 1-(4-bromophenyl)prop-2-en-1-one 
• 140672-35-1 bis(4-bromophenacyltriphenylphosphorane)copper chloride 
• 765314-94-1 [(4-BrC₆H₄C(O))(trifluoroacetatomercurio)methyl]triphenylphosphonium bromide 
• 943436-54-2 (Z)-1-(4-bromophenyl)-3-(3,5-dichlorophenyl)-4,4,4-trifluoro-2-butene-1-one 

Relevant articles and documents

Substituent effects in the formation of a few acenaphthenone-2-ylidene ketones and their molecular docking studies and in silico ADME profile

We observed intriguing substituent effects in the reaction between 4-substituted acetophenones and acenaphthenequinone in the presence of KOH in methanol. In all cases, expected Claisen-Schimdt condensation was the first step. However, depending on the nature of 4-substituent on acetophenone, the initially formed condensation product remain unchanged or underwent Domino sequence of reactions to give three different 2:2 adducts arising through three distinct pathways. The interactions of acenaphthenone-2-ylidene ketones with the target proteins were performed by molecular docking studies. The prediction of in silico ADME belongings of the synthesized compounds revealed substantial drug-likeness characters based on Lipinski's rules.

One-pot synthesis of new hydantoin (thiohydantoin) derivatives and evaluation of their antibacterial and antioxidant activities

One-pot four-component reactions of phenacyl bromides, parabanic or thioparabanic acids, thiophenols, and triphenylphosphine in the presence of triethylamine afforded new derivatives of hydantoin or thiohydantoin in good to high yields (65%-90%). Their an

PYRROLIDINE DERIVATIVES AS PPAR AGONISTS

The present invention discloses a class of pyrrolidine derivatives as PPAR agonist, and their use for the treatment of some diseases of PPAR receptor-associated pathways (such as nonalcoholic steatohepatitis and concurrent fibrosis, insulin resistance, primary biliary cholgangitis, dyslipidenmia, hyperlipidemia, hypercholesterolemia, atherosclerosis, hypertriglyceridemia, cardiovascular disease, obesity or the like). In particular, the present invention discloses a compound represented by Formula (I) or a pharmaceutically acceptable salt thereof.