29325-28-8

Basic information

• Product Name: 4H-Cyclopenta-1,3-dioxole,4-ethenyltetrahydro-6-methoxy-2,2-dimethyl-,(3aR,4R,6R,6aS)-(9CI)
• CAS NO: 29325-28-8
• Molecular Weight: 200.235
• Mol File: 29325-28-8.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 4H-Cyclopenta-1,3-dioxole,4-ethenyltetrahydro-6-methoxy-2,2-dimethyl-,(3aR,4R,6R,6aS)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-Cyclopenta-1,3-dioxole,4-ethenyltetrahydro-6-methoxy-2,2-dimethyl-,(3aR,4R,6R,6aS)-(9CI)(29325-28-8)
• EPA Substance Registry System: 4H-Cyclopenta-1,3-dioxole,4-ethenyltetrahydro-6-methoxy-2,2-dimethyl-,(3aR,4R,6R,6aS)-(9CI)(29325-28-8)

Safety Data

• Hazardous Substances Data: 29325-28-8(Hazardous Substances Data)

Upstream product

• 33985-40-9 (3aR,4S,6R,6aR)-tetrahydro-6-methoxy-2,2-dimethylfuro-[3,4-d][1,3]dioxole-4-carbaldehyde 
• 2065-66-9 methyl-triphenylphosphonium iodide 
• 4099-85-8 ((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 532-20-7 D-Ribose 
• 136136-22-6 ((4R,5S)-5-(hydroxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl acetate 
• 55904-12-6 ((4R,5S)-5-Hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-methanol 
• 1256911-56-4 (E,2S,3R)-2,3-isopropylidenedioxy-6-(tetrahydro-2H-pyran-2-yl)oxy-4-hexenol 
• 1256911-55-3 (E,4R,5S)-6-(tert-butyldimethylsilyl)oxy-4,5-isopropylidenedioxy-1-(tetrahydropyran-2-yl)oxy-2-hexene 
• 1256911-54-2 (E)-3-((4R,5S)-5-(((tert-butyldimethylsilyl)oxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)prop-2-en-1-ol 
• 179237-62-8 (2S,3S)-2,3-O-isopropylidene-2,3,4-trihydroxybutanal tert-butyldimethylsilyl ether 
• 1256911-53-1 ((4R,5S)-5-(((tert-butyldimethylsilyl)oxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)methanol 
• 1256911-52-0 (2R,3S)-4-(tert-butyldimethylsilyl)oxy-2,3-isopropylidenedioxybutyl acetate 
• 67-56-1 methanol 

Downstream Products

• 532-20-7 D-Ribose 
• 33019-63-5 (2R,3R,4R,5R)-2-benzyloxymethyl-3,4-isopropylidenedioxy-5-methoxytetrahydrofuran 
• 23568-35-6 5-O-benzyl-D-ribofuranose 
• 4099-85-8 ((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol 
• 494211-85-7 methyl 5,6,8-trideoxy-2,3-O-(1-methylethylidene)-7-S-phenyl-7-thio-β-D-ribo-oct-7-enofuranoside 
• 3253-94-9 5-deoxy-D-ribo-hexofuranose 
• 864941-60-6 (2R,3R,3aR,6S,7R,7aR)-7-azido-2-(6'-benzoylamino-purin-9'-yl)-6-methoxy-3-pivaloyloxy-hexahydrofuro[3,2-b]pyran 
• 828914-53-0 (1'R,2R,3R,4S,5S)-4-azido-2-(1'-benzoyloxy-2',2'-bisphenylsulfanylethyl)-5-methoxy-tetrahydropyran-3-ol 
• 864941-79-7 (2R,3R,4S,5S)-4-Azido-2-((R)-1-benzyloxy-2,2-bis-phenylsulfanyl-ethyl)-5-methoxy-tetrahydro-pyran-3-ol 
• 828914-61-0 [(2R,3R,3aS,6S,7R,7aR)-3-hydroxy-2-(2',4'-dioxo-3',4'-dihydro-2H-pyrimidin-1'-yl)-6-methoxy-hexahydrofuro[3,2-b]pyran-7-yl]-urea 
• 828914-54-1 (1'R,2R,3R,4S,5S)-4-azido-2-(1'-hydroxy-2',2'-bis-phenylsulfanylethyl)-5-methoxy-tetrahydropyran-3-ol 
• 828914-56-3 (2R,3R,3aR,6S,7R,7aR)-7-azido-hexahydro-6-methoxy-2-(phenylthio)-2H-furo[3,2-b]pyran-3-yl pivalate 
• 828914-52-9 (2R,3R,3aR,6S,7R,7aR)-7-azido-3-benzoyloxy-2,6-dimethoxy-hexahydrofuro[3,2-b]pyran 
• 828914-51-8 (2R,3R,3aR,6S,7R,7aR)-7-azido-3-benzyloxy-2,6-dimethoxy-hexahydrofuro[3,2-b]pyran 

Relevant articles and documents

PRMT5 INHIBITORS

The present invention provides a compound of Formula (I) or the pharmaceutically acceptable salts thereof, which are PRMT5 inhibitors.

A novel pentose synthesis via palladium(II)-catalyzed cyclization of an unstable hemiacetal

PdCl2(PhCN)2 (5 mol%)-catalyzed cyclization of a hemiacetal derived from (E,2S,3R)-2,3-isopropylidenedioxy-6-(tetrahydro-2H- pyran-2-yl)-4-hexenal and methanol gave substituted furanoside in moderate yield, exclusively via 5-exo-mode cyclization, without the need for a reoxidant. New stereogenic centers at C1 and C4 on the tetrahydrofuran ring showed preferential 1R and 4R stereochemistry due to anomeric effect (n oσ*c-o) and A1,2 strain, respectively. This methodology was applied to stereocontrolled synthesis of pentoses: D-ribose and L-lyxose. The Japan Institute of Heterocyclic Chemistry.

5′-Homoaristeromycin. Synthesis and antiviral activity against orthopox viruses

An efficient synthesis of 5′-homoaristeromycin has been developed. This permitted an extensive antiviral analysis, which found potent activity toward vaccinia, cowpox, and monkeypox viruses. For comparative purposes, 5′-homoadenosine was made available by a newly designed route and found to be inactive.