2933-53-1

Basic information

• Product Name: 2-(methyl(o-tolyl)amino)ethan-1-ol
• Synonyms: 2-(methyl(o-tolyl)amino)ethan-1-ol
• CAS NO: 2933-53-1
• Molecular Weight: 165.235
• Mol File: 2933-53-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(methyl(o-tolyl)amino)ethan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(methyl(o-tolyl)amino)ethan-1-ol(2933-53-1)
• EPA Substance Registry System: 2-(methyl(o-tolyl)amino)ethan-1-ol(2933-53-1)

Safety Data

• Hazardous Substances Data: 2933-53-1(Hazardous Substances Data)

Upstream product

• 56-81-5 glycerol 
• 611-21-2 N,2-dimethylaniline 
• 87-72-9 D-Xylose 
• 95-53-4 o-toluidine 
• 50-00-0 formaldehyd 
• 136-80-1 2-(2-tolylamino)ethan-1-ol 

Relevant articles and documents

Ru-Catalyzed Switchable N-Hydroxyethylation and N-Acetonylation with Crude Glycerol

Highly efficient Ru-catalyzed selective C?C or C?O bond cleavage of polyols (e.g., crude glycerol) for N-hydroxyethylation or N-acetonylation of amines was achieved through the hydrogen-borrowing approach. A variety of amines were transformed to the desired amino alcohols/ketones in moderate-to-excellent yields, opening up new avenues for generation of oxygenated pharmaceuticals and fine chemicals from renewable raw materials. The use of new redox-active catalysts containing bisphosphine/thienylmethylamine ligands allows this hydrogen-borrowing system to be operated selectively under both basic and acidic conditions.

Palladium-catalyzed intramolecular carbene insertion into C(sp3)-H bonds

A palladium-catalyzed carbene insertion into C(sp3)-H bonds leading to pyrrolidines was developed. The coupling reaction can be catalyzed by both Pd0 and PdII, is regioselective, and shows a broad functional group tolerance. This reaction is the first example of palladium-catalyzed C(sp3)-C(sp3) bond assembly starting from diazocarbonyl compounds. DFT calculations revealed that this direct C(sp3)-H bond functionalization reaction involves an unprecedented concerted metalation-deprotonation step. Pd in action: Palladium has been used to catalyze the C(sp3)-H insertion of metal carbenoids derived from α-diazoesters to form pyrrolidines through intramolecular assembly of C(sp3)-C(sp3) bonds. A reaction mechanism involving a metalation-deprotonation step instead of the usual concerted but asynchronous process is proposed.