2935-90-2Relevant articles and documents
Additive-Free Green Light-Induced Ligation Using BODIPY Triggers
Li, Ming,Dove, Andrew P.,Truong, Vinh X.
, p. 2284 - 2288 (2020)
Photochemical ligation is important in biomaterials engineering for spatiotemporal control of biochemical processes. Such reactions however generally require activation by high energy UV or short wavelength blue light, which can limit their use as a consequence of the potential of these high energy light sources to damage living cells. Herein, we present an additive-free, biocompatible, chemical ligation triggered by mild visible light. BODIPY dyes with a pendant thioether attached at the meso-position undergo photolysis of the [C?S] bond under green light (λ=530 nm) excitation, producing an ion pair intermediate that can react specifically with a propiolate group. The utility of this photochemical ligation in materials science is demonstrated by the fabrication of hydrogels with specific architectures, photo-immobilization of biomacromolecules, and live cell encapsulation within a hydrogel scaffold.
Danehy,Oester
, p. 1491,1492 (1967)
Method for preparing methyl 3-mercaptopropionate by utilizing reactive distillation technology
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Paragraph 0022-0027, (2021/09/04)
The invention relates to the technical field of organic synthesis, in particular to a method for preparing methyl 3-mercaptopropionate by utilizing a reactive distillation technology. The method comprises the following steps: mixing reactants 3-thiohydracrylic acid and methanol, and pre-reacting through a fixed bed reactor filled with a catalyst to obtain a methyl 3-thiohydracrylate crude product; feeding the crude product to the middle of a reactive distillation tower through a feeding pump to be input, feeding fresh methanol and a water-carrying agent from the lower part of the reactive distillation tower, wherein the lower part of the reactive distillation tower is filled with a catalyst; and carrying out a reaction on the unreacted 3-mercaptopropionic acid in the crude product and methanol continue in a catalyst bed layer of the reactive distillation tower; after the reaction is finished, withdrawing excessive methanol, the water-carrying agent and water from the upper part of the reactive distillation tower, and withdrawing the product methyl 3-mercaptopropionate from the bottom of the tower. By means of the reaction rectification technology, methyl 3-mercaptopropionate and water are separated from a reaction system in time, the reaction time is shortened, the reaction efficiency is improved, and the effect is obvious.
Unusual multistep reaction of C70Cl10 with thiols producing C70[SR]5H
Khakina, Ekaterina A.,Peregudov, Alexander S.,Yurkova, Anastasiya A.,Piven, Natalya P.,Shestakov, Alexander F.,Troshin, Pavel A.
, p. 1215 - 1219 (2016/03/01)
We report a reaction of the chlorofullerene C70Cl10 with thiols producing C70[SR]5H with all organic addends attached around one central pentagon at the pole of the C70 cage. This reaction was shown to proceed via a complicated radical pathway, presumably involving addition, substitution, rearrangement, and/or elimination steps. The obtained C70[SR]5H products were shown to be very unstable and undergo quantitative decomposition to pristine C70, RSSR, and RSH at elevated temperatures (e.g., 50 °C). Quantum chemical calculations and NMR spectroscopy data showed that cleavage of organic addends from the fullerene cage could be induced by solvation effects in solution.
