294866-41-4

Basic information

• Product Name: L-2-(4-BROMOPHENYL)-1,3-THIAZOLANE-4-CARBOXYLIC ACID
• Synonyms: L-2-(4-BROMOPHENYL)-1,3-THIAZOLANE-4-CARBOXYLIC ACID
• CAS NO: 294866-41-4
• Molecular Formula: C₁₀H₁₀BrNO₂S
• Molecular Weight: 288.16
• Mol File: 294866-41-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 474°C at 760 mmHg
• Flash Point: 240.5°C
• Appearance: /
• Density: 1.629g/cm³
• Vapor Pressure: 8.64E-10mmHg at 25°C
• Refractive Index: 1.638
• CAS DataBase Reference: L-2-(4-BROMOPHENYL)-1,3-THIAZOLANE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: L-2-(4-BROMOPHENYL)-1,3-THIAZOLANE-4-CARBOXYLIC ACID(294866-41-4)
• EPA Substance Registry System: L-2-(4-BROMOPHENYL)-1,3-THIAZOLANE-4-CARBOXYLIC ACID(294866-41-4)

Safety Data

• Hazardous Substances Data: 294866-41-4(Hazardous Substances Data)

Usage

General Description

L-2-(4-Bromophenyl)-1,3-thiazolane-4-carboxylic acid is a compound consisting of a thiazole ring with a carboxylic acid group and a 4-bromophenyl substituent. It is a heterocyclic compound with potential pharmacological properties, and it may have applications in medicinal chemistry and drug development. The presence of the bromophenyl group suggests that it could potentially exhibit biological activity, and its structural features make it a candidate for further research in the development of new drugs or therapeutic agents. Additionally, its unique chemical structure may make it useful for various organic synthesis and chemical processes.

InChI:InChI=1/C10H10BrNO2S/c11-7-3-1-6(2-4-7)9-12-8(5-15-9)10(13)14/h1-4,8-9,12H,5H2,(H,13,14)

Upstream product

• 52-90-4 L-Cysteine 
• 1122-91-4 4-bromo-benzaldehyde 

Downstream Products

• 1188543-76-1 (4R)-2-(4-bromophenyl)-3-(tert-butoxycarbonyl)thiazolidine-4-carboxylic acid 
• 110078-93-8 (2S,4R)-3-Acetyl-2-(4-bromo-phenyl)-thiazolidine-4-carboxylic acid 
• 110078-82-5 (2R,4R)-3-Acetyl-2-(4-bromo-phenyl)-thiazolidine-4-carboxylic acid 

Relevant articles and documents

Discovery of cysteine and its derivatives as novel antiviral and antifungal agents

Based on the structure of the natural product cysteine, a series of thiazolidine-4-carboxylic acids were designed and synthesized. All target compounds bearing thiazolidine-4-carboxylic acid were characterized by1 H-NMR,13 C-NMR, and

Chemically controlled amplified ratiometric fluorescence in surface-immobilized end-capped oligo(p-phenylene ethynylene)s

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Discovery of 2-arylthiazolidine-4-carboxylic acid amides as a new class of cytotoxic agents for prostate cancer

To improve the selectivity and antiproliferative activity of previously reported serine amide phosphates (SAPs), we designed a new series of 4-thiazolidinone amides, in which the 4-thiazolidinone moiety was introduced as a phosphate mimic. However, these 4-thiazolidinone derivatives demonstrated less cytotoxicity in prostate cancer cells despite improved selectivity over RH7777 cells. To further optimize the thiazolidinone analogues in terms of cytotoxicity and selectivity, we made closely related structural modifications, which led us to the discovery of a new class of 2-arylthiazolidine-4-carboxylic acid amides. These compounds were potent cytotoxic agents with IC50 values in the low micromolar concentration range and demonstrated enhanced selectivity in receptor-negative cells compared to SAPs and 4-thiazolidinone amides.