29588-91-8

Basic information

• Product Name: PHT-MET-OH
• Synonyms: PHT-MET-OH;PHTHALOYL-L-METHIONINE;(2S)-2-(1,3-Dioxoisoindoline-2-yl)-4-(methylthio)butyric acid;(2S)-2-[(1,3-Dioxo-1,3-dihydro-2H-isoindole)-2-yl]-4-(methylthio)butyric acid;(S)-1,3-Dihydro-α-[2-(methylthio)ethyl]-1,3-dioxo-2H-isoindole-2-acetic acid;(αS)-1,3-Dihydro-α-[2-(methylthio)ethyl]-1,3-dioxo-2H-isoindole-2-acetic acid;N,N-Phthaloyl-L-methionine
• CAS NO: 29588-91-8
• Molecular Formula: C₁₃H₁₃NO₄S
• Molecular Weight: 279.31
• Mol File: 29588-91-8.mol
• Article Data: 10

Chemical Properties

• Melting Point: 124 °C(Solv: water (7732-18-5); methanol (67-56-1))
• Boiling Point: 606.2 °C at 760 mmHg
• Flash Point: 320.4 °C
• Appearance: /
• Density: 1.368 g/cm³
• Vapor Pressure: 1.5E-15mmHg at 25°C
• Refractive Index: 1.605
• PKA: 3.45±0.10(Predicted)
• CAS DataBase Reference: PHT-MET-OH(CAS DataBase Reference)
• NIST Chemistry Reference: PHT-MET-OH(29588-91-8)
• EPA Substance Registry System: PHT-MET-OH(29588-91-8)

Safety Data

• Hazardous Substances Data: 29588-91-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H15NO5S/c1-20-7-6-10(13(18)19)14-11(15)8-4-2-3-5-9(8)12(16)17/h2-5,10H,6-7H2,1H3,(H,14,15)(H,16,17)(H,18,19)

Upstream product

• 85-44-9 phthalic anhydride 
• 63-68-3 L-methionine 
• 59-51-8 DL-methionine 

Downstream Products

• 23631-84-7 (S_CS_S)-L-methionine sulfoxide 
• 3226-66-2 (S_CR_S)-L-methionine sulfoxide 
• 109541-75-5 methyl 1-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)cyclopropanecarboxylate 
• 55985-04-1 methyl (S)-4-methylsulfanyl-2-phthalimidobutanoate 
• 39739-05-4 methyl-(S)-2-phthalimido-4-methylthiobutanoate 
• 146983-84-8 (S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-4-methanesulfinyl-butyric acid methyl ester 
• 155095-09-3 ethyl (S)-4-(methylthio)-2-phthalimidobutanoate 
• 120831-43-8 N,N-phthaloyl-methionine-(N-diphenylacetyl-p-toluidide) 

Relevant articles and documents

1,2-Hydride Migration in Dialkyl α-Diazophosphonates Catalyzed by [Cu(MeCN)4]PF6: A Novel Approach to β-Amino (E)-Enylphosphonates

The regiospecific and stereoselective 1,2-migration reaction of dialkyl α-diazophosphonates for the synthesis of β-amino (E)-enylphosphonates is developed utilizing tetrakis(acetonitrile)copper(I) hexafluorophosphate [Cu(MeCN)4PF6] as the catalyst and N,N-dimethylformamide as an additive. A possible mechanism for the 1,2-migration reaction involving a metal carbene is presented. An investigation on the E/Z isomer selectivity of this process demonstrates that steric factors play an important role on the outcome. This process provides a straightforward access to β-amino (E)-enylphosphonates in moderate to good yields.

Trifluoroborane-catalyzed C-H functionalization/S-H insertion reaction: Construction of N,S-acetal quaternary centers

Abstract The trifluoroborane-catalyzed C-H functionalization/S-H insertion reaction of α-diazophosphonates with thiols has been developed. A plausible reaction mechanism has been proposed to understand the combined reaction. This process provides straightforward access to N,S-acetals containing quaternary centers in moderate to good yields and chemoselectivity.