29601-98-7

Basic information

• Product Name: N-Benzylhydroxylamine hydrochloride
• Synonyms: N-BENZYLHYDROXYLAMINE HYDROCHLORIDE;Benzenemethanamine, N-hydroxy-, hydrochloride;N-hydroxy-BenzeneMethanaMine hydrochloride;BenzeneMethanaMine,N-hydroxy-, hydrochloride (1:1);N-Benzylhydroxylamine hydrochloride 97%;N-benzylhydroxylamine hydrochloride, N-benzyl-N-hydroxylamine hydrochloride, benzyl-hydroxylamine monohydrochloride, benzyl hydroxylamine hydrochloride, o-benzylhydroxyamine hydrochloride, O-benzylhydroxyamine HCl, N-hydroxy-1-phenylmethanamine hydrochloride;N-Benzylhydroxylamine hydrochloride≥ 98%(HPLC)
• CAS NO: 29601-98-7
• Molecular Formula: C₇H₁₀NO*Cl
• Molecular Weight: 159.61
• Product Categories: Hydroxylamines;Nitrogen Compounds;Organic Building Blocks
• Mol File: 29601-98-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 108-110 °C(lit.)
• Boiling Point: 253.9 °C at 760 mmHg
• Flash Point: 135.2 °C
• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• BRN: 507948
• CAS DataBase Reference: N-Benzylhydroxylamine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: N-Benzylhydroxylamine hydrochloride(29601-98-7)
• EPA Substance Registry System: N-Benzylhydroxylamine hydrochloride(29601-98-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• F: 3-10
• Hazardous Substances Data: 29601-98-7(Hazardous Substances Data)

Usage

Chemical Properties

White crystalline

Uses

N-Benzylhydroxylamine hydrochloride may be used in the preparation of a precursor to hitherto unknown aminocyclopentitol derivative, hydroxy functionalised 4-exo-ethoxycarbonyl-3-oxa-2-azabicyclo[3.3.0]octane system.

General Description

N-Benzylhydroxylamine hydrochloride is a N-substituted-hydroxylamine. It participates in the ring opening of (2S,3R)-1,2-epoxy-4-penten-3-ol. Two-step synthesis of N-benzylhydroxylamine starting from dibenzylamine is reported.

Biochem/physiol Actions

N-Benzylhydroxylamine is a potential pharmacological agent in the prevention and progression of acrolein-induced damage to the retinal pigment epithelium.

InChI:InChI:1S/C7H9NO.ClH/c9-8-6-7-4-2-1-3-5-7;/h1-5,8-9H,6H2;1H

Upstream product

• 85407-77-8 N-Benzyl-p-fluorobenzohydroxamic acid 
• 103-49-1 dibenzylamine 
• 932-90-1 Benzaldoxime 
• 100-46-9 benzylamine 
• 128349-14-4 Benzyl-(2,3-dimethoxy-benzyl)-amine 
• 95982-61-9 o-nitro-N-benzyl(benzylamine) 
• 3376-26-9 N-Benzylidenebenzylamine N-oxide 
• 868775-52-4 C-(2,3-dimethoxyphenyl)-N-benzyl-nitrone 
• 22661-22-9 C-(2-nitrophenyl)-N-benzyl-nitrone 
• 162522-31-8 N-benzyl-N-hydroxy-4-nitrobenzamide 
• 7339-99-3 N-benzylbenzohydroxamic acid 
• 622-30-0 N-benzyl hydroxylalmine 

Downstream Products

• 3376-26-9 N-Benzylidenebenzylamine N-oxide 
• 79722-21-7 tert-butyl N-(benzyloxy)carbamate 
• 129487-04-3 (1R,2R,4S,5R,6R,7S,10S)-12-Benzyl-4-methoxy-3,8,11-trioxa-12-aza-tricyclo[8.2.1.0^2,7]tridecane-5,6-diol 
• 129487-02-1 (3aR,5aS,6R,7R,8S,9aR,9bS)-1-Benzyl-8-methoxy-octahydro-2,5,9-trioxa-1-aza-cyclopenta[a]naphthalene-6,7-diol 
• 86582-37-8 N-Benzyl-2-hydroxy-2-(3-thienyl)-acetohydroxamsaeure 
• 140173-69-9 dibenzyl P-<1-(N-benzyl-hydroxyamino)-1-methylethyl>phosphonate 
• 320780-01-6 N-(2-hydroxyethylidene)phenylmethanamine N-oxide 
• 191721-03-6 (Z)-N-benzyl-(3-O-benzyl-1,2-O-isopropylidene-5-deoxy-α-D-ribofuranos-5-ylidene)amine N-oxide 
• 162740-21-8 (Z)-N-benzyl-(3-O-benzyl-1,2-O-isopropylidene-α-D-xylofuranos-5-ylidene)amine N-oxide 
• 170164-31-5 C₁₉H₁₃F₆NO₃ 
• 170164-33-7 C₁₉H₁₄F₆N₂O₂ 
• 3378-36-7 α,α-azodioxytoluene 

Relevant articles and documents

Method for preparing N -benzylhydroxylamine hydrochloride with high yield

The invention discloses a method for preparing N - benzylhydroxylamine hydrochloride in a high yield, which comprises the following steps: S01, taking dibenzylamine as a starting raw material, adding a solvent, a catalyst and dropwise adding first oxidant

Profiling base excision repair glycosylases with synthesized transition state analogs

Two base excision repair glycosylase (BER) transition state (TS) mimics, (3R,4R)-1-benzyl (hydroxymethyl) pyrrolidin-3-ol (1NBn) and (3R,4R)- (hydroxymethyl) pyrrolidin-3-ol (1N), were synthesized using an improved method. Several BER glycosylases that repair oxidized DNA bases, bacterial formamidopyrimdine glycosylase (Fpg), human OG glycosylase (hOGG1) and human Nei-like glycosylase 1 (hNEIL1) exhibit exceptionally high affinity (K d～pM) with DNA duplexes containing the 1NBn and 1N nucleotide. Notably, comparison of the Kd values of both TS mimics relative to an abasic analog (THF) in duplex contexts paired opposite C or A suggest that these DNA repair enzymes use distinctly different mechanisms for damaged base recognition and catalysis despite having overlapping substrate specificities.

One-pot synthesis and hydroxylaminolysis of asymmetrical acyclic nitrones

Aromatic aldehydes 1 were reductively aminated to the corresponding secondary amines 2 using NaBH4 in methanol in good yields. Amines 2 were oxidized with H2O2-WO42- regioselectively to nitrones 3, the structures of which were easily determined by reacting them with hydroxylamine hydrochloride as well as by spectral means. The products of hydroxylaminolysis in ether proved to be the corresponding benzaldehyde oximes 4 and benzyl or methyl hydroxylamine hydrochlorides 5. Copyright Taylor & Francis, Inc.