29604-19-1

Basic information

• Product Name: 1-Piperazinesulfonamide,4-methyl-(8CI,9CI)
• Synonyms: 1-Piperazinesulfonamide,4-methyl-(8CI,9CI);4-METHYLPIPERAZINE-1-SULFONAMIDE;N-sulfamoyl-N'-methylpiperazine
• CAS NO: 29604-19-1
• Molecular Formula: C₅H₁₃N₃O₂S
• Molecular Weight: 179.24
• Product Categories: SULFONAMIDE;PIPERIDINE
• Mol File: 29604-19-1.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Piperazinesulfonamide,4-methyl-(8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperazinesulfonamide,4-methyl-(8CI,9CI)(29604-19-1)
• EPA Substance Registry System: 1-Piperazinesulfonamide,4-methyl-(8CI,9CI)(29604-19-1)

Safety Data

• Hazardous Substances Data: 29604-19-1(Hazardous Substances Data)

Usage

Chemical class

Piperazine derivatives

Functional group

Sulfonamide (consists of a sulfonyl group attached to an amine group)

Structural feature

Methyl group attached to the piperazine ring

Potential applications

Pharmaceutical industry (due to biological activities of piperazine derivatives)

Extensive study or documentation

Not available

Upstream product

• 109-01-3 1-methyl-piperazine 
• 1688-95-5 4-methyl-piperazin-1-ylsulphonyl chloride 
• 866490-11-1 tert-butyl 4-methylpiperazin-1-ylsulfonylcarbamate 

Relevant articles and documents

Diversely substituted sulfamides for fragment-based drug discovery of carbonic anhydrase inhibitors: synthesis and inhibitory profile

A series of sulfamide fragments has been synthesised and investigated for human carbonic anhydrase inhibition. One of the fragments showing greater selectivity for cancer-related isoforms hCA IX and XII was co-crystalized with hCA II showing significant potential for fragment periphery evolution via fragment growth and linking. These opportunities will be identified in the future via the screening of this fragment structure for co-operative carbonic anhydrase binding with other structurally diverse fragments.

SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME

The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts, solvates and prodrugs thereof: Formula (I) wherein Q is selected from O, S and Se; J is S or Se; W1 and W2, when present, are independe

PYRIMIDINE SULPHONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS

A compound of formula (1), or a pharmaceutically acceptable salt, solvate or in vivo hydrolysable ester thereof and pharmaceutical compositions comprising these, all for use in the treatment of chemokine mediated diseases and disorders.