296280-80-3Relevant articles and documents
Design, synthesis and pharmacological evaluation of novel naphthalenic derivatives as selective MT1 melatoninergic ligands
Mésangeau, Christophe,Pérès, Basile,Descamps-Fran?ois, Carole,Chavatte, Philippe,Audinot, Valérie,Coumailleau, Sophie,Boutin, Jean A.,Delagrange, Philippe,Bennejean, Caroline,Renard, Pierre,Caignard, Daniel H.,Berthelot, Pascal,Yous, Sa?d
scheme or table, p. 3426 - 3436 (2010/11/04)
Novel heterodimer analogues of melatonin were synthesized, when agomelatine (1) and various aryl units are linked via a linear alkyl chain through the methoxy group. The compounds were tested for their actions at melatonin receptors. Several of these liga
Synthesis of nitroindole derivatives with high affinity and selectivity for melatoninergic binding sites MT3
Leclerc, Véronique,Yous, Sa?d,Delagrange, Philippe,Boutin, Jean A.,Renard, Pierre,Lesieur, Daniel
, p. 1853 - 1859 (2007/10/03)
The aim of this study was to synthesize selective ligands for melatoninergic subtype receptors that could elucidate the physiological role of melatonin (N-acetyl-5-methoxytryptamine, 1). So, we first investigated the role of a nitro substituent in the 4-,