29699-89-6

Basic information

• Product Name: 4-Nitro Sulfamethoxazole
• Synonyms: 4-Nitro Sulfamethoxazole;N-(5-methyl-3-isoxazolyl)-4-nitrobenzenesulfonamide
• CAS NO: 29699-89-6
• Molecular Formula: C₁₀H₉N₃O₅S
• Molecular Weight: 283.26056
• Product Categories: Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 29699-89-6.mol
• Article Data: 13

Chemical Properties

• Melting Point: 193-195°C (dec.)
• Boiling Point: 497.6°C at 760 mmHg
• Flash Point: 254.8°C
• Appearance: /
• Density: 1.55g/cm³
• Vapor Pressure: 4.87E-10mmHg at 25°C
• Refractive Index: 1.628
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly, Heated)
• PKA: 5.65±0.40(Predicted)
• CAS DataBase Reference: 4-Nitro Sulfamethoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Nitro Sulfamethoxazole(29699-89-6)
• EPA Substance Registry System: 4-Nitro Sulfamethoxazole(29699-89-6)

Safety Data

• Hazardous Substances Data: 29699-89-6(Hazardous Substances Data)

Usage

Chemical Properties

Tan Solid

InChI:InChI=1/C10H9N3O5S/c1-7-6-10(11-18-7)12-19(16,17)9-4-2-8(3-5-9)13(14)15/h2-6H,1H3,(H,11,12)

Upstream product

• 1072-67-9 5-methylisoxazol-3-ylamine 
• 122-04-3 4-nitro-benzoyl chloride 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 723-46-6 sulfamethoxazole 
• 18607-98-2 N¹-acetylsulfamethoxazole 

Downstream Products

• 6455-45-4 N-(4-amino-benzenesulfonyl)-N-(4-iodo-5-methyl-isoxazol-3-yl)-acetamide 
• 94622-36-3 4-benzoylamino-N-(5-methyl-isoxazol-3-yl)-benzenesulfonamide 
• 6455-43-2 N-(4-iodo-5-methyl-isoxazol-3-yl)-N-(4-nitro-benzenesulfonyl)-acetamide 
• 6455-46-5 N-(4-amino-benzenesulfonyl)-N-(4-iodo-5-methyl-isoxazol-3-yl)-benzamide 
• 6455-44-3 N-(4-iodo-5-methyl-isoxazol-3-yl)-N-(4-nitro-benzenesulfonyl)-benzamide 
• 94548-36-4 {4-[acetyl-(5-methyl-isoxazol-3-yl)-sulfamoyl]-phenyl}-carbamic acid benzyl ester 
• 93188-51-3 [4-(5-methyl-isoxazol-3-ylsulfamoyl)-phenyl]-carbamic acid ethyl ester 
• 6455-27-2 N-(4-iodo-5-methyl-isoxazol-3-yl)-N-methanesulfonyl-4-nitro-benzenesulfonamide 
• 6455-29-4 N-(4-iodo-5-methyl-isoxazol-3-yl)-N-(4-nitro-benzenesulfonyl)-toluene-4-sulfonamide 
• 95956-33-5 N,N'-bis-(5-methyl-isoxazol-3-yl)-N,N'-(4,4'-diazenediyl-bis-benzenesulfonyl)-bis-acetamide 
• 21312-10-7 N-acetylsulfamethoxazole 
• 93865-68-0 N-(4-acetylamino-benzenesulfonyl)-N-(5-methyl-isoxazol-3-yl)-acetamide 
• 1024-37-9 Sulfiodizole 
• 121-57-3 4-aminobenzene sulfonic acid 

Relevant articles and documents

Modification of existing antibiotics in the form of precursor prodrugs that can be subsequently activated by nitroreductases of the target pathogen

The use of existing antibiotics in the form of prodrug followed by activation using enzymes of pathogenic origin could be a useful approach for antimicrobial therapy. To investigate this idea, a common antibiotic, sulfamethoxazole has been redesigned in t

Insights into the electrochemical degradation of sulfamethoxazole and its metabolite by Ti/SnO2-Sb/Er-PbO2 anode

Electrochemical degradation of sulfamethoxazole (SMX) and its metabolite acetyl-sulfamethoxazole (Ac-SMX) by Ti/SnO2-Sb/Er-PbO2 were investigated. Results indicated that the electrochemical degradation of SMX and Ac-SMX followed pseu

Effects of water environmental factors on the photocatalytic degradation of sulfamethoxazole by AgI/UiO-66 composite under visible light irradiation

It is necessary to find visible light responsive photocatalysts for rapid and simple degradation of organic pollutants in water environment. In this work, a visible light responsive composite photocatalyst AgI/UiO-66 was prepared by an in situ growth method. Sulfamethoxazole (SMZ) antibiotic was selected as the target contaminant to probe the photocatalytic performance of the as-prepared AgI/UiO-66 composite under visible light irradiation. The results showed that the photocatalytic performance of the AgI/UiO-66 composite enhanced significantly compared to pure AgI. The effects of typical environment factors (i.e. pH, inorganic salt ions and common anions) on the degradation of SMZ were evaluated extensively. Results showed that the investigated pH (5.2, 7.0, 9.5) had no apparent effect on the photocatalytic degradation of SMZ except pH 2.5, at which the degradation rate of SMZ decreased significantly. In addition, inorganic salt ions and Cl?, HCO3? and SO42? anions in water exhibited no apparent effect on the degradation of SMZ. The effect of water matrix on the degradation of SMZ was also investigated. In the river water, the removal efficiency of SMZ was reduced compared with the cleaner water matrix. The capture experiments of radicals confirmed that superoxide radicals ([rad]O2?) and hydroxyl radicals ([rad]OH) were the main active species for the photocatalytic degradation of SMZ in the present work. Finally, the tentative degradation pathways of SMZ were proposed based on the intermediates analysis.