297172-72-6Relevant articles and documents
The synthesis and hepatoprotective activity of esters of the lupane group triterpenoids
Flekhter,Karachurina,Poroikov,Nigmatullina,Baltina,Zarudii,Davydova,Spirikhin,Baikova,Galin,Tolstikov
, p. 192 - 200 (2000)
Hemisuccinates, hemiphthalates, acetylsalicylates, cinnamates, and p-methoxycinnamates of lupeol, betulin, and 3-O-acetylbetulin were synthesized via interaction with corresponding acid anhydrides or acid chlorides. A number of betulin esters in position 3 and 28 were shown to exhibit a pronounced hepatoprotective effect similar to that of betulin and silibor. These experimental data were in a good agreement with the computer prediction of their biological activity. Betulin 3,28-bishemiphthalate was more effective than carsil in models of experimental hepatitis caused by carbon tetrachloride, tetracycline, and ethanol.
