2973-10-6

Basic information

• Product Name: DIISOPROPYL SULFATE
• Synonyms: diisopropyltetraoxosulfate;isopropylsulfate;sulfuricacid,bis(1-methylethyl)ester;sulfuricacid,diisopropylester;DIISOPROPYL SULFATE;Diisopropylsulfate(ep);dipropan-2-yl sulfate;di-isopropylsulfat
• CAS NO: 2973-10-6
• Molecular Formula: C₆H₁₄O₄S
• Molecular Weight: 182.24
• EINECS: 221-011-9
• Mol File: 2973-10-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: -19 °C
• Boiling Point: 94 °C / 7mmHg
• Flash Point: 96.8°C
• Appearance: /
• Density: 1.10
• Vapor Pressure: 0.0724mmHg at 25°C
• Refractive Index: 1.4070-1.4110
• Storage Temp.: Freezer
• Water Solubility: Slightly soluble in water
• CAS DataBase Reference: DIISOPROPYL SULFATE(CAS DataBase Reference)
• NIST Chemistry Reference: DIISOPROPYL SULFATE(2973-10-6)
• EPA Substance Registry System: DIISOPROPYL SULFATE(2973-10-6)

Safety Data

• RIDADR: 1760
• RTECS: WS8050000
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 2973-10-6(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid; sharp odor; boils around120°C (248°F) at 30 torr; density 1.11;slightly soluble in water; miscible with alcohol and ether.

Health Hazard

This substance is moderately toxic by ingestion and skin contact (Lewis 1996). Itstoxicity, however, is lower than the ethylderivative. The evidence of its carcino-genic potency is inadequate. IARC has listedthis substance as “possibly carcinogenic tohuman” (group B carcinogen) (IARC 1998).LD50 , oral (rat): ～1100 mg/kgLD50 , skin (rabbit): ～1400 mg/kg.

InChI:InChI=1/C6H14O4S/c1-5(2)9-11(7,8)10-6(3)4/h5-6H,1-4H3

Upstream product

• 116-17-6 triisopropyl phosphite 
• 187737-37-7 propene 
• 7664-93-9 sulfuric acid 
• 4773-13-1 diisopropyl sulfite 
• 67-63-0 isopropyl alcohol 
• 683-60-3 sodium isopropylate 

Downstream Products

• 98-82-8 Isopropylbenzene 
• 6380-20-7 3-isopropylanisole 
• 1860-27-1 butyl isopropyl ether 
• 538-93-2 1-phenyl-2-methylpropane 
• 2741-16-4 isopropoxybenzene 
• 598-23-2 3-methyl-but-1-yne 
• 75-31-0 isopropylamine 
• 108-18-9 diisopropylamine 
• 1004-77-9 2-isopropylcyclohexanone 
• 91358-59-7 t-butyl 4-isopropoxy-2-methylcyclohexa-1,3-diene-1-carboxylate 
• 37826-18-9 diisopropyl diselenide 
• 7515-80-2 N-isopropyl-N-tert-butylamine 
• 3054-95-3 acrylaldehyde diethyl acetal 
• 64-17-5 ethanol 

Relevant articles and documents

Preparation method of nitro compound

The invention discloses a preparation method of a nitro compound, which comprises: carrying out a reaction on a compound 1A and a compound 1B to obtain a compound 2A; and reacting the compound 2A witha nitration reagent to obtain a nitro compound crude product, and purifying to obtain a nitro compound fine product. According to the method, a reagent with low price is used as an initial raw material to prepare the final product through two-step reaction, wherein the reaction condition of each step is mild, the yield of the obtained nitro compound is high, and the cost can be greatly reduced.

Direct transformation of dialkyl sulfates into alkyllithium reagents by a naphthalene-catalysed lithiation

The lithiation of primary and secondary dialkyl sufates with an excess of lithium powder in the presence of a catalytic amount of naphthalene (4 mol %) in THF at -78°C leads to the corresponding alkyllithium reagents (1:2 molar ratio) which react with different electrophiles, mainly carbonyl compounds, to yield after hydrolysis, the expected coupling products. This methodology represents an indirect way to transform alcohols into organolithium compounds through the corresponding dialkyl sulfates. When the same procedure is applied to five or six member cyclic sulfates (derived from 1,2- or 1,3-diols) only products arising from a β- or γ-elimination process (giving olefins or cyclopropanes), respectively, are obtained.