29808-81-9

Basic information

• Product Name: 2-NITROACRIDINE
• Synonyms: 2-NITROACRIDINE;2-Nitroacridine 97%
• CAS NO: 29808-81-9
• Molecular Formula: C₁₃H₈N₂O₂
• Molecular Weight: 224.21
• Mol File: 29808-81-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 210-212 °C
• Boiling Point: 435.2 °C at 760 mmHg
• Flash Point: 217 °C
• Appearance: /
• Density: 1.377 g/cm³
• Vapor Pressure: 2.27E-07mmHg at 25°C
• Refractive Index: 1.754
• PKA: 3.59±0.10(Predicted)
• CAS DataBase Reference: 2-NITROACRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-NITROACRIDINE(29808-81-9)
• EPA Substance Registry System: 2-NITROACRIDINE(29808-81-9)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 29808-81-9(Hazardous Substances Data)

Usage

General Description

2-Nitroacridine is a chemical compound with the molecular formula C13H8N2O2. It is a derivative of acridine and consists of a nitro group at the 2-position of the acridine ring. 2-NITROACRIDINE is known for its use in organic synthesis and as an intermediate in the production of pharmaceuticals and dyes. It is also used as a building block in the synthesis of various heterocyclic compounds. 2-Nitroacridine has shown potential as a fluorescent probe for detecting DNA damage and has been studied for its potential use in cancer therapy. Additionally, it is a known mutagen and has been used in research to study the mutagenic properties of nitroaromatic compounds.

InChI:InChI=1/C13H8N2O2/c16-15(17)11-5-6-13-10(8-11)7-9-3-1-2-4-12(9)14-13/h1-8H

Upstream product

• 260-94-6 acridine 
• 529-23-7 o-aminobenzaldehyde 
• 586-78-7 para-nitrophenyl bromide 
• 62-53-3 aniline 
• 6361-21-3 2-chloro-5-nitrobenzaldehyde 
• 7697-37-2 nitric acid 
• 98-95-3 nitrobenzene 
• 1200798-52-2 C₁₃H₁₀N₂O₂ 
• 92-81-9 acridine 
• 20682-61-5 7-nitro-9-chloroacridine 

Downstream Products

• 7251-00-5 2-nitroacridone 
• 581-28-2 2-aminoacridine 

Relevant articles and documents

Simple and convenient conversion of acridones into 9-unsubstituted acridines via acridanes using borane tetrahydrofuran complex

A new method for the synthesis of 9-unsubstituted acridines from acridones using mild conditions is described. Various acridines bearing reduction-sensitive group(s) have been synthesized from the corresponding acridones using a two-step procedure that involved a commercially available borane complex reduction followed by an acridane oxidation.

The Preparation of Some 2-Nitroacridines and Related Compounds

The reaction of 2-fluoro-5-nitrobenzaldehyde with a wide variety of arylamines gives, in general, mixtures of the corresponding 2-arylamino-5-nitrobenzaldehydes and their related anils.Both aldehydes and anils readily underwent acid-catalysed cyclization to give the corresponding 2-nitroacridines.The effect of substituent on the rate of cyclization of these aldehydes and of some related anilino-benzaldehydes and -acetophenones has been studied in trifluoroacetic acid solution by means of 1H n.m.r. spectroscopy.A solution of 2-(N-methylanilino)-5-nitrobenzaldehydein trifluoroacetic acid appears to contain a substituted acridinium ion; treatment of this solution with alkali gave 10-methyl-2-nitroacridone. 1H n.m.r. data for a wide variety of substituted 2-nitroacridines are discussed.