2985-79-7

Basic information

• Product Name: 4'-chloro-2-hydroxybenzophenone
• Synonyms: 4'-chloro-2-hydroxybenzophenone
• CAS NO: 2985-79-7
• Molecular Weight: 232.666
• Mol File: 2985-79-7.mol
• Article Data: 24

Chemical Properties

• Melting Point: 77–78°C
• CAS DataBase Reference: 4'-chloro-2-hydroxybenzophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-chloro-2-hydroxybenzophenone(2985-79-7)
• EPA Substance Registry System: 4'-chloro-2-hydroxybenzophenone(2985-79-7)

Safety Data

• Hazardous Substances Data: 2985-79-7(Hazardous Substances Data)

Usage

Uses

4’-Chloro-2-hydroxy-benzophenone is a useful compound to investigate the effects of substituents on photo-antioxidant abilities of 2-hydroxybenzoyl compounds that can?prevent?autooxidation of plastics under UV light.4’-Chloro-2-hydroxy-benzophenone can also utilized to develop novel?Azomethine Prodrugs of (R)-α-Methylhistamine.

Preparation

Preparation by Fries rearrangement of phenyl p-chloro-benzoate, ? with aluminium chloride without solvent between 120° and 160°, (29%), at 200° for 20 min or in refluxing chlorobenzene for 10 h (53%); ? with trifluoromethanesulfonic acid at 45–55° (6%).

Upstream product

• 108-90-7 chlorobenzene 
• 1441-87-8 salicyloyl chloride 
• 637-87-6 1-Chloro-4-iodobenzene 
• 90-02-8 salicylaldehyde 
• 104-88-1 4-chlorobenzaldehyde 
• 108-95-2 phenol 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 1195709-59-1 C₁₄H₉ClO₂ 
• 106-39-8 bromochlorobenzene 
• 4846-21-3 O-phenylhydroxylamine 
• 98-80-6 phenylboronic acid 
• 64908-64-1 2-phenoxyisoindol-1,3-dione 
• 5661-50-7 N-(phenoxy)acetamide 
• 1820-42-4 bis(4-chlorophenyl)acetylene 

Downstream Products

• 1579264-47-3 C₂₁H₁₅ClO₂ 
• 57329-30-3 3-(4'-chlorophenyl)benzofuran 
• 451503-28-9 (α¹R)-4-chloro-α-phenyl-benzenemethanamine hydrochloride 
• 163837-57-8 (R)-(4-chlorophenyl)(phenyl)methylamine 
• 1334247-23-2 (S)-2-(amino(4-chlorophenyl)methyl)phenol 
• 1334334-91-6 2-((4-chlorophenyl)(imino)methyl)phenol 

Relevant articles and documents

Water-Tolerant ortho-Acylation of Phenols

A metal-free, water-tolerant, and one-pot process for ortho-acylation of phenols promoted by the iodine source/hydrogen peroxide system has been developed. This transformation undergoes ether formation, iodocyclization, C-C bond cleavage, and oxidative hydrolysis in a one-step manner, which is supported by control experiments.

Cu/Ag mediated peroxide-free synthesis of benzoylated naphthol derivatives

A peroxide-free methodology was developed for the synthesis of benzoylated naphthol/phenol derivatives through oxidative deamination reaction performed under aerobic reaction conditions. A synergistic combination of Cu(OTf)2 and Ag2O was used to convert the aminonaphthols and aminophenols to the corresponding benzoylated derivatives. The definite role of atmospheric oxygen to assist the reaction was proved by performing the reaction in the argon atmosphere.

Ruthenium-Catalyzed Direct Asymmetric Reductive Amination of Diaryl and Sterically Hindered Ketones with Ammonium Salts and H2

A Ru-catalyzed direct asymmetric reductive amination of ortho-OH-substituted diaryl and sterically hindered ketones with ammonium salts is reported. This method represents a straightforward route toward the synthesis of synthetically useful chiral primary diarylmethylamines and sterically hindered benzylamines (up to 97 % yield, 93–>99 % ee). Elaborations of the chiral amine products into bioactive compounds and a chiral ligand were demonstrated through manipulation of the removable and convertible -OH group.