2987-06-6

Basic information

• Product Name: 4-(Benzyloxy)cyclohexanone
• Synonyms: 4-(Benzyloxy)cyclohexane-1-one;4-(Benzyloxy)cyclohexanone;4-(Phenylmethoxy)cyclohexanone;4β-(Benzyloxy)cyclohexanone;4-(Benzyloxy)cyclohexan-1-one;4-phenylmethoxycyclohexan-1-one
• CAS NO: 2987-06-6
• Molecular Formula: C₁₃H₁₆O₂
• Molecular Weight: 204.27
• Product Categories: Aromatics;Intermediates
• Mol File: 2987-06-6.mol
• Article Data: 36

Chemical Properties

• Boiling Point: 319.923 °C at 760 mmHg
• Flash Point: 139.072 °C
• Appearance: /
• Density: 1.073 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.532
• Storage Temp.: -20?C Freezer
• Solubility: Chloroform, Dichloromethane, Ethyl Acetate, Methanol
• CAS DataBase Reference: 4-(Benzyloxy)cyclohexanone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Benzyloxy)cyclohexanone(2987-06-6)
• EPA Substance Registry System: 4-(Benzyloxy)cyclohexanone(2987-06-6)

Safety Data

• Hazardous Substances Data: 2987-06-6(Hazardous Substances Data)

Usage

Chemical Properties

Light Yellow Oil

Synthesis Reference(s)

Synthetic Communications, 26, p. 1789, 1996 DOI: 10.1080/00397919608002619

InChI:InChI=1/C13H16O2/c14-12-6-8-13(9-7-12)15-10-11-4-2-1-3-5-11/h1-5,13H,6-10H2

Upstream product

• 67-56-1 methanol 
• 84029-18-5 (1RS,3RS,6SR)-3-(benzyloxy)-7-oxabicyclo[4.1.0]heptane 
• 84049-33-2 (1SR,3RS,6RS)-3-(benzyloxy)-7-oxabicyclo[4.1.0]heptane 
• 13482-22-9 4-hydroxycyclohexanone 
• 100-44-7 benzyl chloride 
• 556-48-9 1,4-Cyclohexanediol 
• 100-39-0 benzyl bromide 
• 69125-55-9 4-hydroxy-1-methoxy-1-cyclohexene 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 22428-87-1 4,4-ethylenedioxycyclohexan-1-ol 
• 445481-11-8 (1S*,2R*,4S*)-4-(benzyloxy)-1,2-epoxycyclohexane 
• 154410-53-4 8-Benzyloxy-2-(4-methoxy-phenyl)-1,4-dioxa-spiro[4.5]decane 
• 92829-83-9 1,4-dioxaspiro<4,5>decan-8-ol benzyl ether 
• 2976-80-9 4-(benzyloxy)cyclohexan-1-ol 

Downstream Products

• 100710-69-8 5-(benzyloxy)-2-oxocyclohexane-1-carbonitrile 
• 53491-28-4 8-(4-benzyloxy-cyclohexyl)-4-ethyl-1-oxa-3,8-diaza-spiro[4.5]decan-2-one 
• 75802-42-5 4-(benzyloxy)-1-vinylcyclohexanol 
• 85559-30-4 4-(benzyloxy)-2-(methylthio)cyclohexanone 
• 82732-16-9 4-(benzyloxy)-1-(3,4-dimethoxyphenyl)cyclohex-1-ene 
• 130745-63-0 4-Benzyloxy-1-methyl-cyclohexanol 
• 130745-62-9 4-Benzyloxy-1-methyl-cyclohexanol 
• 104847-57-6 (4aS,5R)-5-Benzenesulfonyl-2-benzyloxy-6,11-dimethoxy-1,3,4,5,12,12a-hexahydro-2H-naphthacen-4a-ol 
• 154410-53-4 8-Benzyloxy-2-(4-methoxy-phenyl)-1,4-dioxa-spiro[4.5]decane 
• 127074-29-7 trans-4-(benzyloxy)cyclohexanol 
• 127074-28-6 cis-4-(benzyloxy)cyclohexanol 
• 47566-28-9 1-<3.5-Dimethoxy-phenoxy>-4-benzyloxy-cyclohexan-carbonsaeure-(1) 
• 2987-07-7 4-Hydroxy-2,2,6,6-tetrapropyl-cyclohexanon 
• 187800-61-9 4-benzyloxy-1-(trimethylsilyloxy)cyclohexane-1-carbonitrile 

Relevant articles and documents

CYCLIC CYANOENONE DERIVATIVES AS MODULATORS OF KEAP1

The present invention relates to cyclic cyanoenone derivatives of Formula (I) or pharmaceutically acceptable salts or solvates thereof, wherein R1, R2, R3, R4 and m are as defined herein. The present invention also relates to pharmaceutical compositions comprising the cyclic cyanoenone derivatives of Formula (I) and to their use in therapy.

Hydrogen Borrowing Catalysis with Secondary Alcohols: A New Route for the Generation of β-Branched Carbonyl Compounds

A hydrogen borrowing reaction employing secondary alcohols and Ph? (Me5C6) ketones to give β-branched carbonyl products is described (21 examples). This new C-C bond forming process requires low loadings of [Cp?IrCl2]2, relatively low temperatures, and up to 2.0 equiv of the secondary alcohol. Substrate-induced diastereoselectivity was observed, and this represents the first example of a diastereoselective enolate hydrogen borrowing alkylation. By utilizing the Ph? group, the β-branched products could be straightforwardly cleaved to the corresponding esters or amides using a retro-Friedel-Crafts reaction. Finally, this protocol was applied to the synthesis of fragrance compound (±)-3-methyl-5-phenylpentanol.

AMINOACYLINDAZOLE IMMUNOMODULATORS FOR TREATMENT OF AUTOIMMUNE DISEASES

2-Acylindazole compounds of formula I or formula II are disclosed. These compounds inhibit Coagulation Factor XIIa. They are useful to treat autoimmune diseases.